An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester
An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester
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DOI：
10.1016/s0040-4039(01)01416-2
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发表时间：
2001-09-24
影响因子：
1.8
通讯作者：
Kennedy, TP
中科院分区：
文献类型：
--
作者：
Tian, QP;Nayyar, NK;Kennedy, TP
采用N-Boc-L-（+）-谷氨酸二甲酯的关键不对称双阴离子氰甲基化反应，开发了一条制备鼻病毒蛋白酶抑制剂AG 7088的关键中间体的有效合成路线。该方法能够以千克的量制备该化合物，总产率为30%。(C)2001爱思唯尔科技有限公司版权所有。
An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogram quantities with an overall yield of 30%. (C) 2001 Elsevier Science Ltd. All rights reserved.