Activity in Preserved Left Hemisphere Regions Predicts Anomia Severity in Aphasia
Activity in Preserved Left Hemisphere Regions Predicts Anomia Severity in Aphasia
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DOI：
10.1093/cercor/bhp160
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发表时间：
2010-05-01
期刊：
影响因子：
3.7
通讯作者：
Rorden, Chris
中科院分区：
文献类型：
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作者：
Fridriksson, Julius;Bonilha, Leonardo;Rorden, Chris
理解失语症中支持保留语言处理的神经机制对基础科学和应用科学都有意义。这项研究检查了15名失语症患者的大脑活动与正确命名图片的关系。我们将每个患者的激活与在神经健康对照组中观察到的激活进行了对比，使我们能够识别出异常活动模式的区域。结果显示，在失语症患者中，保留的左半球区域的激活增加与更好的命名能力有关。这种关系本质上是线性的；逐渐减少的皮质激活与更严重的异常有关。这些发现与其他人的观点一致，他们认为中风后残留的语言功能依赖于左半球保留的皮层区域。
Understanding the neural mechanism that supports preserved language processing in aphasia has implications for both basic and applied science. This study examined brain activation associated with correct picture naming in 15 patients with aphasia. We contrasted each patient's activation to the activation observed in a neurologically healthy control group, allowing us to identify regions with unusual activity patterns. The results revealed that increased activation in preserved left hemisphere areas is associated with better naming performance in aphasia. This relationship was linear in nature; progressively less cortical activation was associated with greater severity of anomia. These findings are consistent with others who suggests that residual language function following stroke relies on preserved cortical areas in the left hemisphere.