Inactivation of parietal and prefrontal cortex reveals interdependence of neural activity during memory-guided saccades
Inactivation of parietal and prefrontal cortex reveals interdependence of neural activity during memory-guided saccades
复制标题
DOI：
10.1152/jn.2000.83.3.1550
复制
发表时间：
2000-03-01
影响因子：
2.5
通讯作者：
Goldman-Rakic, PS
中科院分区：
文献类型：
--
作者：
Chafee, MV;Goldman-Rakic, PS
顶叶和前额叶皮层的失活揭示了记忆引导扫视期间神经活动的相互依赖性。 J.神经生理学。 83: 1550-1566, 2000。背外侧前额叶和后顶叶皮层共享相互投影。在执行记忆引导的扫视过程中，它们也具有几乎相同的神经元激活模式。为了检验顶叶神经元和前额叶神经元之间的相互投射可能导致其并行激活的假设，本实验将一个皮质区域的皮质冷却与另一个皮质区域的单单元记录相结合，以更精确地确定工作记忆表现期间两者之间的生理相互作用。在执行动眼神经延迟反应 (ODR) 任务期间（43 个顶叶神经元在前额叶冷却过程中，62 个前额叶神经元在顶叶冷却过程中），对在远端皮层区域保持正常体温或冷却时收集的两组试验进行了比较，比较了 105 个皮层神经元的活动。当顶叶皮层冷却时，ODR 表演期间 71% 的前额叶神经元的平均放电率发生显着变化。在任务的提示、延迟或扫视期间其活动受到调节的前额叶神经元同样容易受到顶叶失活的影响。此外，相对于预冷期，较低和较高的点火率的频率相当。从相反的实验中也得到了类似的结果，其中 76% 的顶叶神经元的平均放电率在前额皮质冷却时显着不同，特别是在这些任务中。在 ODR 执行过程中调节每个神经元的活动的时期。这些影响再次以增强或抑制活动的形式在 ODR 任务的所有时期中同样出现。无论区域冷却如何，在任务的提示和扫视期间，对神经元激活潜伏期的显着影响都不存在。在某些情况下，冷却与神经元活动的高斯调谐功能的最佳方向的变化有关，并且这些变化在顶叶冷却期间平均比前额叶冷却期间更大。鉴于先前报道的活动模式的相似性与目前获得的基本对称的冷却效应之间的相似性，数据表明，前额叶和顶叶神经元在 ODR 表现期间通过它们之间神经元信号的对称交换实现匹配的激活；在两个皮质区域中，在 ODR 任务的提示、延迟和扫视时期激活的神经元参与相互的神经传递；每个皮质区域的输出在其目标范围内产生兴奋性和抑制性驱动的混合。
Inactivation of parietal and prefrontal cortex reveals interdependence of neural activity during memory-guided saccades. J. Neurophysiol. 83: 1550-1566, 2000. Dorsolateral prefrontal and posterior parietal cortex share reciprocal projections. They also share nearly identical patterns of neuronal activation during performance of memory-guided saccades. To test the hypothesis that the reciprocal projections between parietal and prefrontal neurons may entrain their parallel activation, the present experiments have combined cortical cooling in one cortical area with single-unit recording in the other to more precisely determine the physiological interactions between the two during working memory performance. The activity of 105 cortical neurons during the performance of an oculomotor delayed response (ODR) task (43 parietal neurons during prefrontal cooling, 62 prefrontal neurons during parietal cooling) was compared across two blocks of trials collected while the distant cortical area either was maintained at normal body temperature or cooled. The mean firing rates of 71% of the prefrontal neurons during ODR performance changed significantly when parietal cortex was cooled. Prefrontal neurons the activity of which was modulated during the cue, delay, or saccade periods of the task were equally vulnerable to parietal inactivation. Further, both lower and higher firing rates relative to the precool period were seen with comparable frequency. Similar results were obtained from the converse experiment, in which the mean firing rates of 76% of the parietal neurons were significantly different while prefrontal cortex was cooled, specifically in those task. epochs when the activity of each neuron was modulated during ODR performance. These effects again were seen equally in all epochs of the ODR task in the form of augmented or suppressed activity. Significant effects on the latency of neuronal activation during cue and saccade periods of the task were absent irrespective of the area cooled. Cooling was associated in some cases with a shift in the best direction of Gaussian tuning functions lit to neuronal activity, and these shifts were on average larger during parietal than prefrontal cooling. In view of the parallel between the similarity in activity patterns previously reported and the largely symmetrical cooling effects presently obtained, the data suggest that prefrontal and parietal neurons achieve matched activation during ODR performance through a symmetrical exchange of neuronal signals between them; in both cortical areas, neurons activated during the cue, delay, and also saccade epochs of the ODR task participate in reciprocal neurotransmission; and the output of each cortical area produces a mixture of excitatory and inhibitory drives within its target.