A mechanobiological perspective on cadherins and the actin-myosin cytoskeleton.
A mechanobiological perspective on cadherins and the actin-myosin cytoskeleton.
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DOI：
10.12703/p5-35
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发表时间：
2013-09-02
期刊：
影响因子：
--
通讯作者：
Yap, Alpha S
中科院分区：
文献类型：
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作者：
Budnar, Srikanth;Yap, Alpha S
经典钙粘蛋白受体介导身体许多组织内的形态发生细胞-细胞相互作用。它们的生物学影响往往需要钙粘蛋白粘附和肌动蛋白细胞骨架之间的合作，但这可能如何发生，以及-更紧迫的是-这如何导致形态发生的结果是仍然知之甚少的问题。在这里，我们认为，新兴领域的钙粘蛋白机械生物学提供了一个有用的新的角度来重新审视这些问题。我们建议，肌动蛋白细胞骨架可以被认为是一种活性剂，介导钙粘蛋白连接如何抵抗，感觉和细胞之间的反作用力。
Classical cadherin receptors mediate morphogenetic cell-cell interactions within many tissues of the body. Their biological impact often entails cooperation between cadherin adhesion and the actin cytoskeleton, but how this may occur and - even more urgently - how this leads to morphogenetic outcomes are questions that remain poorly understood. Here, we suggest that the emerging field of cadherin mechanobiology provides a useful new perspective from which to revisit these issues. We propose that the actin cytoskeleton can be considered as an active agent that mediates how cadherin junctions resist, sense and transduce forces between cells.