Synthetic Metallomolecules as Agents for the Control of DNA Structure
Synthetic Metallomolecules as Agents for the Control of DNA Structure
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DOI：
10.1002/chin.200725222
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发表时间：
2007-06
期刊：
影响因子：
--
通讯作者：
Adair D. Richards;A. Rodger
中科院分区：
文献类型：
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作者：
Adair D. Richards;A. Rodger
本教程综述总结了B-DNA结构和金属分子结合模式，并说明了一些DNA结构诱导的分子含有金属阳离子。水合金属离子，钴胺，钌八面体金属配合物，金属helicates和铂配合物，如顺铂的影响进行了讨论旁边的NMR，X射线晶体学，凝胶电泳，圆二色性，线性二色性和分子动力学技术。该评论将感兴趣的人感兴趣的DNA结构和金属分子在生物系统中的作用。
This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes, metallohelicates and platinum complexes such as cis-platin are discussed alongside the techniques of NMR, X-ray crystallography, gel electrophoresis, circular dichroism, linear dichroism and molecular dynamics. The review will be of interest to people interested in both DNA structure and roles of metallomolecules in biological systems.