Cdc42 and Cellular Polarity: Emerging Roles at the Golgi.
Cdc42 and Cellular Polarity: Emerging Roles at the Golgi.
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DOI：
10.1016/j.tcb.2015.11.003
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发表时间：
2016-04
影响因子：
19
通讯作者：
Hsu VW
中科院分区：
文献类型：
--
作者：
Farhan H;Hsu VW
Cdc42属于小gtpase的Rho家族，在细胞极性事件中起关键作用。Cdc42的这一作用通常归因于其在质膜上的功能。然而，Cdc42也存在于高尔基复合体中。在这篇综述中，我们总结了在Cdc42的高尔基池研究中收集到的主要见解，并提出高尔基定位的Cdc42使Cdc42的功能多样化，这些功能在某些情况下代表了新的作用，在其他情况下作为Cdc42在质膜上的既定作用的补充。对Cdc42如何作用于高尔基体的研究也提出了未来需要解决的关键问题。
Cdc42 belongs to the Rho family of small GTPases and plays key roles in cellular events of polarity. This role of Cdc42 has typically been attributed to its function at the plasma membrane. However, Cdc42 also exists at the Golgi complex. In this review, we summarize major insights that have been gathered in studying the Golgi-pool of Cdc42 and propose that Golgi-localized Cdc42 enables the cell to diversify the function of Cdc42, which in some cases represent new roles, and in other cases act to complement the established roles of Cdc42 at the plasma membrane. Studies on how Cdc42 acts at the Golgi also suggest key questions to address in the future.