Sexually Dimorphic Outcomes after Neonatal Stroke and Hypoxia-Ischemia.
Sexually Dimorphic Outcomes after Neonatal Stroke and Hypoxia-Ischemia.
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DOI：
10.3390/ijms19010061
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发表时间：
2017-12-26
影响因子：
5.6
通讯作者：
Baud O
中科院分区：
文献类型：
--
作者：
Charriaut-Marlangue C;Besson VC;Baud O
队列研究表明，男性在近足月或足月出生的婴儿中更容易遭受缺血性和/或缺氧缺血性损伤。男性还与新生儿中风和缺氧缺血后的大脑修复有限有关，与具有类似脑损伤的女性相比，导致长期认知缺陷的发生率增加。因此，将性别视为重要变量的临床前实验设计得到了支持和研究，因为减少脑损伤的神经保护策略表现出性别二态性。虽然强调男孩和女孩之间这些差异的机制尚不清楚，但一些生物过程被认为在长期神经发育结果中发挥关键作用：各个发育阶段的性腺激素、氧化应激的脆弱性、细胞死亡的调节和小胶质细胞激活的调节。本综述总结了新生儿缺氧缺血性和/或缺血性脑损伤中性别差异的当前证据，考虑了已知与发育中大脑损伤相关的认知和行为缺陷的主要途径。
Cohort studies have demonstrated a higher vulnerability in males towards ischemic and/or hypoxic-ischemic injury in infants born near- or full-term. Male sex was also associated with limited brain repair following neonatal stroke and hypoxia-ischemia, leading to increased incidence of long-term cognitive deficits compared to females with similar brain injury. As a result, the design of pre-clinical experiments considering sex as an important variable was supported and investigated because neuroprotective strategies to reduce brain injury demonstrated sexual dimorphism. While the mechanisms underlining these differences between boys and girls remain unclear, several biological processes are recognized to play a key role in long-term neurodevelopmental outcomes: gonadal hormones across developmental stages, vulnerability to oxidative stress, modulation of cell death, and regulation of microglial activation. This review summarizes the current evidence for sex differences in neonatal hypoxic-ischemic and/or ischemic brain injury, considering the major pathways known to be involved in cognitive and behavioral deficits associated with damages of the developing brain.
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DOI：
10.1523/jneurosci.2102-11.2011
发表时间：
2011-09-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Faustino JV;Wang X;Johnson CE;Klibanov A;Derugin N;Wendland MF;Vexler ZS
通讯作者：
Vexler ZS
影响因子：
3
作者：
Golomb, Meredith R.
通讯作者：
Golomb, Meredith R.
影响因子：
3
作者：
Clancy, Barbara;Kersh, Brandon;Finlay, Barbara L.
通讯作者：
Finlay, Barbara L.
影响因子：
1.5
作者：
Hill CA;Fitch RH
通讯作者：
Fitch RH
影响因子：
5.3
作者：
Bonnin, Philippe;Leger, Pierre-Louis;Charriaut-Marlangue, Christiane
通讯作者：
Charriaut-Marlangue, Christiane