Effects of severe hypertension on endothelial and platelet microparticles
Effects of severe hypertension on endothelial and platelet microparticles
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DOI：
10.1161/01.hyp.0000049760.15764.2d
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发表时间：
2003-02-01
期刊：
影响因子：
8.3
通讯作者：
Alm, YS
中科院分区：
文献类型：
--
作者：
Preston, RA;Jy, W;Alm, YS
极端血压升高导致血管损伤的分子机制尚未明确。为了探讨内皮和血小板的激活（表现为循环内皮微粒和血小板微粒浓度的增加）可能在靶器官损伤中发挥作用的假设，我们在三组中对这些标志物进行了横断面研究：(1)专门用于治疗严重不受控制高血压的未经治疗的患者；(2)未治疗的轻度高血压患者；(3)血压正常的志愿者。经方差分析，内皮细胞（P=0.002）和血小板（P=0.01）微粒在重度高血压组最多。即使在多重危险因素的情况下，这些指标和血压之间也存在显著的相关性。我们的研究结果表明，这些标志物可能对高血压患者压力诱导的内皮细胞和血小板活化有用且具有特异性。此外，由于内皮细胞和血小板微粒对凝血、白细胞和内皮细胞的联合作用，它们可能在重度高血压中介导靶器官损伤中起致病作用。
The molecular mechanisms by which extreme blood pressure elevation leads to vascular injury are not defined. To explore the hypothesis that activation of endothelium and platelets as manifested by increased concentrations of circulating endothelial microparticles and platelet microparticles could play a role in this target organ injury, we conducted a cross-sectional study of these markers in 3 groups: (1) untreated patients referred specifically for treatment of severe uncontrolled hypertension; (2) untreated patients with established mild hypertension; and (3) normotensive volunteer subjects. By ANOVA, endothelial (P=0.002) and platelet (P=0.01) microparticles were greatest in the severely hypertensive group. There was a significant correlation between both of these markers and blood pressure, even in the setting of multiple risk factors. Our results suggest that these markers may be useful and specific for pressure-induced endothelial and platelet activation in hypertension. Furthermore, because of the combined effects of endothelial and platelet microparticles on coagulation, leukocytes, and endothelium, it is possible that they may play a pathogenic role in mediating target organ injury in severe hypertension.