Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases
Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases
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DOI：
10.1006/jaut.2002.0622
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发表时间：
2002-12-01
影响因子：
12.8
通讯作者：
Mackay, IR
中科院分区：
文献类型：
--
作者：
Fida, S;Myers, MA;Mackay, IR
SOX 13分子最初被鉴定为1型糖尿病中的自身抗原（ICA 12）。SOX 13是SOX家族转录调节蛋白的成员，其含有与HMG蛋白1和2具有结构相似性的高迁移率族（HMG）基序。HMG 1和2的抗体出现在肝脏的自身免疫性疾病和溃疡性结肠炎中。我们通过放射免疫沉淀法测定了原发性胆汁性肝硬化（PBQ）和其他疾病中抗SOX 13的发生率和水平，并与ELISA法测定的抗HMG的频率进行了比较。在PBC患者中检测到18%的抗-SOX 13，13%的自身免疫性肝炎，18%的1型糖尿病，在其他疾病中的频率较低，包括多系统自身免疫性疾病，系统性红斑狼疮和类风湿性关节炎，并在1%的正常血清。抗HMG 1和抗HMG 2在PBC中的检出率分别为30%和35%。血清抗SOX 13和抗HMG水平与PBC显著相关，但与1型糖尿病无关。PBC中的抗SOX 13可能仅仅作为对实质组织损伤产物的免疫应答而发生，或者可能说明转录调节蛋白引起自身免疫应答的一般倾向。(C)2002爱思唯尔科技有限公司版权所有。
The molecule SOX13 was initially identified as an autoantigen (ICA12) in Type 1 diabetes. SOX13 is a member of the SOX family of transcriptional regulatory proteins that contain a high mobility group (HMG) motif with structural similarity to HMG proteins 1 and 2. Antibodies to HMG 1 and 2 occur in autoimmune diseases of the liver and in ulcerative colitis. We measured the occurrence and levels of anti-SOX13 by radioimmunoprecipitation in primary biliary cirrhosis (PBQ and other diseases, and compared frequencies with anti-HMG measured by ELISA. Anti-SOX13 was detected in 18% of patients with PBC, 13% with autoimmune hepatitis, 18% with Type 1 diabetes, at lower frequencies in other conditions including the multisystem autoimmune diseases, systemic lupus erythematosus and rheumatoid arthritis, and in 1% of normal sera. Anti-HMG1 and anti-HMG2 occurred at frequencies of 30% and 35% respectively in PBC. Serum levels of anti-SOX13 and anti-HMG correlated significantly for PBC although not for Type 1 diabetes. Anti-SOX13 in PBC may occur merely as an immune response to products of damage to parenchymal tissue, or may be illustrative of a general proclivity of transcriptional regulatory proteins to elicit autoimmune responses. (C) 2002 Elsevier Science Ltd. All rights reserved.