Optical coherence tomography for imaging the vulnerable plaque
Optical coherence tomography for imaging the vulnerable plaque
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DOI：
10.1117/1.2192697
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发表时间：
2006-03-01
影响因子：
3.5
通讯作者：
Bouma, Brett E.
中科院分区：
文献类型：
--
作者：
Tearney, Guillermo J.;Jang, Ik-Kyung;Bouma, Brett E.
虽然我们对易损冠状动脉斑块的认识仍处于早期阶段，但某些类型的斑块使患者易于发生急性心肌梗死的概念仍然处于心脏病学研究的最前沿。冠状动脉内光学相干断层扫描（OCT）由于其与其他成像方式相比具有明显的分辨率优势，已被开发用于识别和研究这些病变。我们回顾了过去五年来在马萨诸塞州总医院进行的临床研究，以开发、验证和利用这项技术来提高我们对易损斑块的理解。我们的研究结果表明，冠状动脉内OCT可以安全地进行患者，它提供了丰富的信息斑块的微观形态，这是必不可少的识别和研究的高风险病变。尽管在广泛使用这项技术之前，必须解决许多基本的生物学、临床和技术挑战，但OCT的独特功能确保了它将在塑造心脏病学的未来方面发挥重要作用。(c)2006年，由光学仪器工程师协会（Society of Photo-Optical Instrumentation Engineers）主办。
While our understanding of vulnerable coronary plaque is still at an early stage, the concept that certain types of plaques predispose patients to developing an acute myocardial infarction continues to be at the forefront of cardiology research. Intracoronary optical coherence tomography (OCT) has been developed to both identify and study these lesions due to its distinct resolution advantage over other imaging modalities. We review clinical research conducted at the Massachusetts General Hospital over the past five years to develop, validate, and utilize this technology to improve our understanding of vulnerable plaque. Our results show that intracoronary OCT may be safely conducted in patients and that it provides abundant information regarding plaque microscopic morphology, which is essential to the identification and study of high-risk lesions. Even though many basic biological, clinical, and technological challenges must be addressed prior to widespread use of this technology, the unique capabilities of OCT ensure that it will have a prominent role in shaping the future of cardiology. (c) 2006 Society of Photo-Optical Instrumentation Engineers.