Chronic lymphocytic leukemia associated with myelodysplastic syndrome and/or chronic myeloid leukemia: Evidence for independent clonal chromosomal evolution
Chronic lymphocytic leukemia associated with myelodysplastic syndrome and/or chronic myeloid leukemia: Evidence for independent clonal chromosomal evolution
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DOI：
10.3109/10428190109057988
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发表时间：
2001-04-01
影响因子：
2.6
通讯作者：
Troussard, X
中科院分区：
文献类型：
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作者：
Mossafa, H;Fourcade, C;Troussard, X
我们描述了三例同时或连续发展为B-慢性淋巴细胞白血病(B-CLL)的病例，其中2例为骨髓增生异常综合征(MDS)，1例为慢性髓系白血病(CML)。这两种恶性血液病的共存导致了关于它们起源细胞的问题。通过对细胞遗传学异常的分析，我们研究了这两种恶性肿瘤的起源。同时对这3例患者的外周血和骨髓进行细胞遗传学分析。系统地进行短期刺激(USSTC)和长期(72~96h)刺激培养(LTSC)。在所有情况下，我们都证明了独立的双克隆进化。这是首次报道CLPD和MDS和/或MPD患者由不同的染色体异常引起。
We describe the cytogenetic findings of three cases with simultaneous or sequential development of a B-chronic lymphocytic leukemia (B-CLL) and either a myelodysplastic syndrome (MDS) in 2 cases or a chronic myeloid leukemia (CML) in one case. The coexistence of these two hematologic malignancies leads to questions about their cell of origin. Through analysis of the cytogenetic abnormalities, we studied the derivation of both malignancies. The cytogenetic analyses of these three patients were simultaneously studied from both peripheral blood and bone marrow. Furthermore unstimulated short-time (USSTC) and long-time (72-96 hours) stimulated cultures (LTSC) were systematically performed. In all cases, we have demonstrated the independent bi-clonal evolution. This is the first report ever described for patients with CLPD and MDS and/or MPD shown to arise from distinct chromosomal abnormalities.