Chlorpromazine and pimozide alter reinforcement efficacy and motor performance.
Chlorpromazine and pimozide alter reinforcement efficacy and motor performance.
复制标题
氯丙嗪和匹莫齐特改变强化功效和运动表现。
DOI：
10.1007/bf00180837
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发表时间：
1986
影响因子：
3.4
通讯作者：
Seiden,LS
中科院分区：
文献类型：
--
作者：
Heyman,GM;Kinzie,DL;Seiden,LS
本研究评价氯丙嗪和吡莫胺对强化反应的影响。在每次实验中，大鼠被暴露在一系列五种可变间隔强化计划中。反应要求是按杠杆，奖励是一小部分水，强化率从每小时20到660个强化物不等。响应率是强化率的负加速函数，两个变量之间的关系用矩形双曲线方程（匹配律）来描述。双曲线的一个参数相当于渐近响应率，另一个参数相当于维持1 / 2渐近响应率的强化率。氯丙嗪（0.75-3.0 mg/kg）和吡莫胺（0.1-0.4 mg/kg）的剂量依赖性降低了反应率。在低剂量下，反应率的下降在很大程度上仅限于低强化率计划。相反，测试的最高剂量降低了低和高强化率下的反应率。反应率下降的模式导致匹配律方程参数的剂量依赖性变化。从运动和动机的角度讨论了匹配律参数的变化对抗精神病药引起的反应率变化的解释。
This study evaluated the effects of chlorpromazine and pimozide on reinforced responding. In each session, rats were exposed to a series of five variable-interval reinforcement schedules. The response requirement was a lever press, the reward was a small portion of water, and the reinforcement rate varied from about 20 to 660 reinforcers per hour. Response rate was a negatively accelerated function of reinforcement rate, and the relationship between the two variables was described by the equation for a rectangular hyperbola (the matching law). One parameter of the hyperbola is equivalent to the asymptotic response rate and the other parameter is equivalent to the rate of reinforcement that maintains a one-half asymptotic response rate. Chlorpromazine (0.75–3.0 mg/kg) and pimozide (0.1–0.4 mg/kg) dose-dependently decreased response rates. At low doses, the response rate decreases were, for the most part, restricted to the low reinforcement rate schedules. In contrast, the highest dose tested decreased response rates at both low and high reinforcement rates. The patterns of response rate decreases resulted in dose-dependent changes in the parameters of the matching law equation. The shifts in the matching law parameters were discussed in terms of the motoric and motivational interpretations of neuroleptic-induced response rate changes.