Global structure, robustness, and modulation of neuronal models
Global structure, robustness, and modulation of neuronal models
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DOI：
10.1523/jneurosci.21-14-05229.2001
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发表时间：
2001-07-15
影响因子：
5.3
通讯作者：
Abbott, LF
中科院分区：
文献类型：
--
作者：
Goldman, MS;Golowasch, J;Abbott, LF
面对不断变化的内部和外部条件，许多神经元的电特性都非常稳健。同时，神经元可能对神经调节剂高度敏感。我们在基于电导的模型神经元结构的全局分析中发现了这种双重鲁棒性和敏感性的相关性。我们改变了模型神经元的最大电导参数，对于每一组测试的参数，将细胞产生的活动模式描述为沉默、张力放电或爆发。在模型的五个最大电导的参数空间内，我们找到了方向，表示多个电导的协调变化，神经活动的基本模式不改变。在其他方向上，一些电导的相对较小的并发变化可以诱导这些活动模式之间的转换。电导空间图的全局结构表明，改变敏感电导集的神经调节剂将产生强大的、可能依赖于状态的影响。其他可能对神经元活动没有直接影响的调制器可能通过这种状态依赖性改变这些直接调制器的效果。模型研究的一些结果和预测在使用动态钳的口胃神经节神经元记录中得到了重复和验证。
The electrical characteristics of many neurons are remarkably robust in the face of changing internal and external conditions. At the same time, neurons can be highly sensitive to neuromodulators. We find correlates of this dual robustness and sensitivity in a global analysis of the structure of a conductance-based model neuron. We vary the maximal conductance parameters of the model neuron and, for each set of parameters tested, characterize the activity pattern generated by the cell as silent, tonically firing, or bursting. Within the parameter space of the five maximal conductances of the model, we find directions, representing concerted changes in multiple conductances, along which the basic pattern of neural activity does not change. In other directions, relatively small concurrent changes in a few conductances can induce transitions between these activity patterns. The global structure of the conductance-space maps implies that neuromodulators that alter a sensitive set of conductances wilt have powerful, and possibly state-dependent, effects. Other modulators that may have no direct impact on the activity of the neuron may nevertheless change the effects of such direct modulators via this state dependence. Some of the results and predictions arising from the model studies are replicated and verified in recordings of stomatogastric ganglion neurons using the dynamic clamp.