Associations between brain volumetry and relaxometry signatures and the Edmonton Frail Scale in frailty.
Associations between brain volumetry and relaxometry signatures and the Edmonton Frail Scale in frailty.
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DOI：
10.21037/qims-20-852
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发表时间：
2021-06
影响因子：
2.8
通讯作者：
Chunmei Li;Yuhui Chen;Pu-yeh Wu;Bing Wu;T. Gong;Hua Wang;Min Chen
中科院分区：
文献类型：
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作者：
Chunmei Li;Yuhui Chen;Pu-yeh Wu;Bing Wu;T. Gong;Hua Wang;Min Chen
背景虚弱是一种以储备减少为特征的老年病。埃德蒙顿衰弱量表（EFS）已作为评估工具广泛应用于临床实践。然而，大脑在衰弱过程中潜在的病理生理变化及其与 EFS 的关系仍不清楚。本研究旨在探讨衰弱时大脑容量和松弛测量特征与 EFS（以及 EFS 的每个领域评分）之间的关联。方法 共有 40 名非痴呆受试者参与这项前瞻性研究。根据 EFS 对每个受试者进行衰弱评估。所有受试者均在 3.0 T MR 扫描仪上进行了合成磁共振成像 (MRI)（磁共振图像编译，MAGiC）和三维快速破坏梯度回忆回波 (3D-FSPGR) T1 加权结构图像采集。根据从 MAGiC 和 3D-FSPGR 图像获得的定量值进行脑分割。还获得了全脑和区域灰质（GM）的体积测定和松弛测定。通过部分相关性研究了 EFS 总分（以及每个领域的分数）与大脑体积和松弛测量之间的关联，同时消除了年龄的影响。区域 GM 体积法和松弛测量分析的多重比较由错误发现率 (FDR) 校正控制。所有数据均使用 SPSS 13.0 统计软件包（IBM，Armonk，NY，USA）和 MATLAB（MathWorks，Natick，MA，USA）进行分析。结果 整体容积测量中，多个整体容积参数与EFS、认知评分、功能独立评分、营养评分、功能表现评分之间存在显着相关性（P<0。05）。结论 总之，脑容量和松弛测量特征显示与 EFS 和衰弱的一些 EFS 领域评分有很强的相关性。这些关联可能揭示 EFS 和 EFS 不同领域可能的潜在病理生理学。
Background Frailty is a geriatric condition characterized by a decreased reserve. The Edmonton frailty scale (EFS) has been widely used as an assessment tool in clinical practice. However, the brain's underlying pathophysiological changes in frailty and their associations with the EFS remain unclear. This study aimed to explore the associations between brain volumetry and relaxometry signatures and the EFS (and each domain score of the EFS) in frailty. Methods A total of 40 non-demented subjects were enrolled in this prospective study. Frailty assessment was performed for each subject according to the EFS. All subjects underwent synthetic magnetic resonance imaging (MRI) (MAGnetic resonance image Compilation, MAGiC) and three-dimensional fast spoiled gradient-recalled echo (3D-FSPGR) T1-weighted structural image acquisitions on a 3.0 T MR scanner. Brain segmentation was performed based on quantitative values obtained from the MAGiC and 3D-FSPGR images. Volumetry and relaxometry of the global brain and regional gray matter (GM) were also obtained. The associations between the total EFS score (and the score of each domain) and the brain's volumetry and relaxometry were investigated by partial correlation while eliminating the effects of age. Multiple comparisons of regional GM volumetry and relaxometry analyses were controlled by false discovery rate (FDR) correction. All data were analyzed using the SPSS 13.0 statistical package (IBM, Armonk, NY, USA) and MATLAB (MathWorks, Natick, MA, USA). Results For global volumetry, significant correlations were found between multiple global volumetry parameters and the EFS, as well as the cognition score, functional independence score, nutrition score, and functional performance score (P0.05). Conclusions In conclusion, brain volumetry and relaxometry signatures showed strong associations with the EFS and some EFS domain scores in frailty. These associations may reveal the possible underlying pathophysiology of the EFS and different domains of the EFS.