Pulmonary consequences of transfusion: TRALI and TACO
Pulmonary consequences of transfusion: TRALI and TACO
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DOI：
10.1016/j.transci.2006.01.005
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发表时间：
2006-06-01
影响因子：
1.9
通讯作者：
Popovsky, Mark A.
中科院分区：
文献类型：
--
作者：
Popovsky, Mark A.
输血相关急性肺损伤和输血相关循环超负荷是重要的、危及生命的输血并发症。每一种都对住院时间和医疗费用产生不利影响。TRALI在临床上与成人呼吸窘迫综合征难以区分，但预后更好。大约10%的TRALI患者死于这种并发症。尚未确定TRALI的风险患者。最常引用的发生率是1：5000含血浆成分输血。虽然有几种途径可能导致TRALI，但白细胞抗体的被动输注是目前最重要的关联。1-8%接受髋关节或膝关节置换术的患者发生TACO。它是由正液体平衡和高输液流速引起的。TACO的特征是呼吸窘迫和急性肺水肿。(c)2006爱思唯尔有限公司保留所有权利。
Transfusion-related acute lung injury and transfusion-associated circulatory overload are important, life-threatening complications of transfusion. Each adversely impact hospital length of stay and cost of healthcare. TRALI is clinically indistinguishable from the adult respiratory distress syndrome but it has a more favorable prognosis. Approximately 10% of TRALI patients die from this complication. The at-risk patient for TRALI has not been identified. The most commonly cited incidence is 1:5000 plasma-containing blood component transfusions. Although several pathways may lead to TRALI, passive transfusion of leukocyte antibodies is currently the most important association. TACO occurs in 1-8% of patients undergoing hip or knee arthroplasty. It is precipitated by positive fluid balance and high transfusion flow rates. TACO is characterized by respiratory distress and acute pulmonary edema. (c) 2006 Elsevier Ltd. All rights reserved.