SAFETY OF REGIONAL CITRATE HEMODIALYSIS IN ACUTE RENAL-FAILURE
SAFETY OF REGIONAL CITRATE HEMODIALYSIS IN ACUTE RENAL-FAILURE
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DOI：
10.1016/s0272-6386(89)80126-x
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发表时间：
1989-02-01
影响因子：
13.2
通讯作者：
DIEDERICH, D
中科院分区：
文献类型：
--
作者：
LOHR, JW;SLUSHER, S;DIEDERICH, D
局部柠檬酸盐抗凝是出血风险增加患者血液透析中肝素抗凝的替代方法。我们报告了在49例高出血风险急性肾功能衰竭患者的326次透析中成功使用该技术。任何透析程序均未导致全身抗凝，并且在任何情况下均未观察到出血。根据肌酐清除情况判断，透析有效。无出血并发症和电解质和酸碱异常发生率低证明了该手术的安全性。此外，我们通过连续测量血清柠檬酸盐水平，证明没有柠檬酸盐中毒。局部柠檬酸盐抗凝是一种安全有效的血液透析方法，可用于出血风险增加的急性肾衰竭患者。
Regional citrate anticoagulation is an alternative to heparin anticoagulation for hemodialysis of patients at increased risk of bleeding. We report the successful use of this technique in 326 dialyses in 49 high bleeding risk patients with acute renal failure. Systemic anticoagulation did not occur as a result of any dialysis procedure, and in no instance was bleeding observed. Dialysis was effective, as judged by removal of creatinine. The safety of this procedure is demonstrated by the lack of bleeding complications and the small incidence of electrolyte and acidbase abnormalities. In addition we document the absence of citrate intoxicaton by serial measurements of serum citrate levels. Regional citrate anticoagulation is a safe and effective method of performing hemodialysis in patients with acute renal failure at increased risk of bleeding.