CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives.
CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives.
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DOI：
10.1186/s12931-017-0546-5
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发表时间：
2017-04-12
影响因子：
5.8
通讯作者：
Schmid RA
中科院分区：
文献类型：
--
作者：
Cortes-Dericks L;Schmid RA
摘要恶性胸膜间皮瘤是一种罕见且高度抗药性的肿瘤，发生于肺胸膜的间皮瘤表面。确认MPM的标准方法是对癌症活检进行繁琐、耗时的细胞学检查。在胸腔积液或患者血清中可检测到的生物标志物是提供更快和非侵入性诊断方法的合理选择。目前，MPM的生物标志物缺乏特异性和敏感性来区分这种肿瘤与其他肺肿瘤。CD44是一种多功能表面受体，与包括MPM在内的不同癌症的肿瘤进展有关。CD44与其配体透明质酸（HA）的相互作用已被证明在MPM中调节细胞增殖和侵袭性中起重要作用。特别是，这些分子的高表达水平已显示出MPM的诊断相关性。本文将总结CD44和HA的生物学和诊断意义，以及这两种分子在MPM中的相互作用，这将证明它们作为生物标志物的潜力。目前MPM标志物的增加可能导致这种疾病的早期诊断和管理。
Malignant pleural mesothelioma (MPM) is a rare and highly drug resistant tumor arising from the mesothelial surfaces of the lung pleura. The standard method to confirm MPM is the tedious, time-consuming cytological examination of cancer biopsy. Biomarkers that are detectable in pleural effusion or patient serum are reasonable options to provide a faster and noninvasive diagnostic approach. As yet, the current biomarkers for MPM lack specificity and sensitivity to discriminate this neoplasm from other lung tumors. CD44, a multifunctional surface receptor has been implicated in tumor progression in different cancers including MPM. The interaction of CD44 with its ligand, hyaluronan (HA) has demonstrated an important role in modulating cell proliferation and invasiveness in MPM. In particular, the high expression levels of these molecules have shown diagnostic relevance in MPM. This review will summarize the biology and diagnostic implication of CD44 and HA as well as the interaction of both molecules in MPM that will demonstrate their potential as biomarkers. Augmentation of the current markers in MPM may lead to an earlier diagnosis and management of this disease.