Cross-Sectional Correlation Between Hepatic R2☆ and Proton Density Fat Fraction (PDFF) in Children With Hepatic Steatosis
Cross-Sectional Correlation Between Hepatic R2☆ and Proton Density Fat Fraction (PDFF) in Children With Hepatic Steatosis
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DOI：
10.1002/jmri.25748
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发表时间：
2018-02-01
影响因子：
4.4
通讯作者：
Sirlin, Claude B.
中科院分区：
文献类型：
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作者：
Mamidipalli, Adrija;Hamilton, Gavin;Sirlin, Claude B.
目的：探讨肝脏质子密度脂肪分数（PDFF）与体内R2（star）的关系。材料和方法：在这项符合HIPAA（健康保险可携带性和责任法案）、机构审查委员会（IRB）批准的横断面研究中，我们对3T磁共振成像（MRI）检查进行了二次分析，这些检查作为前瞻性研究的一部分，在临床排除了与铁超载相关的条件的儿童中进行。每次检查包括低翻角、多回波量级（-M）和基于化学位移编码的复杂（-C） MRI技术，以及脂肪的光谱建模，以生成肝脏PDFF和R2（星）参数图。对于每种技术和每个患者，在9个库伊诺节段的图上放置感兴趣的区域，并计算全肝PDFF和R2（星形）值。计算各MRI技术PDFF与R2（星号）之间的Pearson相关系数。使用Steiger检验比较相关性。结果：184名儿童（123名男孩，61名女孩）被纳入本分析。MRI-M和MRI-C估计的PDFF范围分别为1.1-35.4%（9.44 +/- 8.76）和2.1-38.1%（10.1 +/- 8.7）。MRI-M和MRI-C估计的R2（star）分别为32.6-78.7 s(-1)（48.4 +/- 9.8）和27.2-71.5 s(-1)（42.2 +/- 8.6）。肝脏PDFF与MRI-M （r=0.874, P < 0.0001）和MRI-C （r=0.853, P < 0.0001）估计的R2（star）值有很强且显著的相关性。相关系数（0.874比0.853）差异无统计学意义（P = 0.15）。结论：肝脏PDFF与R2（star）在体内呈强相关。使用两种不同的MRI技术观察到这种关系。
Purpose: To determine the relationship between hepatic proton density fat fraction (PDFF) and R2(star) in vivo.Materials and Methods: In this Health Insurance Portability and Accountability Act (HIPAA)-compliant, Institutional Review Board (IRB)-approved, cross-sectional study, we conducted a secondary analysis of 3T magnetic resonance imaging (MRI) exams performed as part of prospective research studies in children in whom conditions associated with iron overload were excluded clinically. Each exam included low-flip-angle, multiecho magnitude (-M) and complex (-C) based chemical-shift-encoded MRI techniques with spectral modeling of fat to generate hepatic PDFF and R2(star) parametric maps. For each technique and each patient, regions of interest were placed on the maps in each of the nine Couinaud segments, and composite whole-liver PDFF and R2(star) values were calculated. Pearson's correlation coefficients between PDFF and R2(star) were computed for each MRI technique. Correlations were compared using Steiger's test.Results: In all, 184 children (123 boys, 61 girls) were included in this analysis. PDFF estimated by MRI-M and MRI-C ranged from 1.1-35.4% (9.44 +/- 8.76) and 2.1-38.1% (10.1 +/- 8.7), respectively. R2(star) estimated by MRI-M and MRI-C ranged from 32.6-78.7 s(-1) (48.4 +/- 9.8) and 27.2-71.5 s(-1) (42.2 +/- 8.6), respectively. There were strong and significant correlations between hepatic PDFF and R2(star) values estimated by MRI-M (r=0.874; P < 0.0001) and MRI-C (r=0.853; P < 0.0001). The correlation coefficients (0.874 vs. 0.853) were not significantly different (P = 0.15).Conclusion: Hepatic PDFF and R2(star) are strongly correlated with each other in vivo. This relationship was observed using two different MRI techniques.