Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space
Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space
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DOI：
10.1111/j.1460-9568.2012.08256.x
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发表时间：
2012-11-01
影响因子：
3.4
通讯作者：
Dunnett, S. B.
中科院分区：
文献类型：
--
作者：
Lelos, M. J.;Harrison, D. J.;Dunnett, S. B.
新纹状体的功能障碍，包括帕金森病和亨廷顿病在内的几种神经退行性疾病的主要特征，已被发现导致对侧刺激的定位和反应受损。在以前的研究结果的基础上，据推测，随着响应选项的偏心率的增加，纹状体细胞的损失可能会损害响应本地化在最远的偏心率水平，而多巴胺（DA）的耗竭可能不会产生不利影响，在这个超个人空间执行的响应。为了更充分地阐明纹状体的功能，本研究探讨了差异的影响，单方面DA耗竭或兴奋性损伤的响应执行在同侧和对侧的空间在多达四个水平的偏心。结果证实，在这两种类型的纹状体功能障碍后，检测刺激的感觉能力保持完整，而在绝对对侧空间直接反应的能力受损。然而，明显的差异，在配置文件的损害，明显的，与DA耗竭后观察到的反应遗漏显着增加，这可能反映了减少动机的处理，和恢复的功能与兴奋性毒性病变，这表明有能力重新学习的大鼠中观察到。此外，数据表明，细胞丢失后，在近对侧空间的反应是由竞争纹状体控制，而在个人以外的空间反应依赖于对侧半球。这些结果的影响，了解纹状体的自我中心定义的反应定位的作用，以及解开行为的影响，纹状体细胞损失或异常DA的传输中观察到的神经退行性疾病。
Dysfunction of the neostriatum, a primary feature of several neurodegenerative disorders, including Parkinsons disease and Huntingtons disease, has been found to result in impaired localisation of, and reaction to, contralateral stimuli. On the basis of previous findings, it is hypothesised that, with increasing eccentricity of the response option, striatal cell loss may impair response localisation at the furthest levels of eccentricity, whereas dopamine (DA) depletion may not impact adversely upon responses executed in this extrapersonal space. In order to elucidate more fully the function of the striatum, the present study examined the differential impact of unilateral DA depletion or excitoxic lesion on response execution in ipsilateral and contralateral space at up to four levels of eccentricity. The results confirmed that, after both types of striatal dysfunction, the sensory ability to detect stimuli remains intact, whereas the ability to direct responses in absolute contralateral space is impaired. Distinct differences in the profiles of impairment were, however, evident, with a marked increase in response omissions observed after DA depletion, which may reflect decreased motivational processing, and recovery of function observed in rats with excitotoxic lesions, which suggests the ability to re-learn. Furthermore, the data demonstrate that, after cell loss, responding in near contralateral space is controlled by competing striata, whereas responding in extrapersonal space relies on the contralateral hemisphere. These results have implications for understanding the role of the striatum in egocentrically defined response localisation, as well as for unravelling the behavioural impact of striatal cell loss or aberrant DA transmission observed in neurodegenerative diseases.