A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model
A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model
复制标题
小分子探针揭示帕金森病模型中线粒体硫氧还蛋白还原酶活性下降
DOI：
10.1039/c5cc09998f
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Fang, Jianguo
中科院分区：
文献类型：
--
作者：
Liu, Yaping;Ma, Huilong;Fang, Jianguo
报道了第一个用于成像活细胞中线粒体硫氧还蛋白还原酶（TrxR2）的开关探针Mito-TRFS。在帕金森病（PD）的细胞模型中，Mito-TRFS染色显示TrxR2活性急剧下降，提供了TrxR2功能障碍与PD病因的机制联系。
The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.