23Na Magnetic Resonance Imaging-Determined Tissue Sodium in Healthy Subjects and Hypertensive Patients
23Na Magnetic Resonance Imaging-Determined Tissue Sodium in Healthy Subjects and Hypertensive Patients
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DOI：
10.1161/hypertensionaha.111.00566
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发表时间：
2013-03-01
期刊：
影响因子：
8.3
通讯作者：
Titze, Jens
中科院分区：
文献类型：
--
作者：
Kopp, Christoph;Linz, Peter;Titze, Jens
高盐饮食摄入与高血压有关;盐敏感性高血压的患病率随年龄增长而增加。我们假设，组织Na+可能积累在高血压患者和老化可能伴随着Na+沉积在组织中。我们较早地在体内实施Na-23磁共振成像来测量软组织的Na+含量，但尚未研究原发性高血压。我们报告了一组56名健康对照男性和女性，以及57名原发性高血压男性和女性。年龄22 ~ 90岁。在小腿水平进行Na-23磁共振成像测量。我们观察到男性肌肉中Na+含量的年龄依赖性增加，而女性肌肉中Na+含量不随年龄变化。我们用常规MRI估计了含水量，发现男性肌肉水分没有与年龄相关的增加，尽管Na+积累显著，表明肌肉中无水Na+储存。随着年龄的增长，有Na+沉积在皮肤中的妇女和男子，但皮肤Na+含量仍然较低的妇女。同样，在皮肤含水量方面也发现了这种性别差异，女性的含水量低于男性。与肌肉相比，Na+含量的增加与皮肤含水量的增加相反。当控制年龄时，我们发现难治性高血压患者与血压正常的对照组相比，组织Na+含量增加。这些观察结果表明，Na-23磁共振成像可以在纵向研究中评估组织Na+储存对心血管发病率和死亡率的作用。（高血压。2013;61：635-640）。circle在线数据补充
High dietary salt intake is associated with hypertension; the prevalence of salt-sensitive hypertension increases with age. We hypothesized that tissue Na+ might accumulate in hypertensive patients and that aging might be accompanied by Na+ deposition in tissue. We implemented Na-23 magnetic resonance imaging to measure Na+ content of soft tissues in vivo earlier, but had not studied essential hypertension. We report on a cohort of 56 healthy control men and women, and 57 men and women with essential hypertension. The ages ranged from 22 to 90 years. Na-23 magnetic resonance imaging measurements were made at the level of the calf. We observed age-dependent increases in Na+ content in muscle in men, whereas muscle Na+ content did not change with age in women. We estimated water content with conventional MRI and found no age-related increases in muscle water in men, despite remarkable Na+ accumulation, indicating water-free Na+ storage in muscle. With increasing age, there was Na+ deposition in the skin in both women and men; however, skin Na+ content remained lower in women. Similarly, this sex difference was found in skin water content, which was lower in women than in men. In contrast to muscle, increasing Na+ content was paralleled with increasing skin water content. When controlled for age, we found that patients with refractory hypertension had increased tissue Na+ content, compared with normotensive controls. These observations suggest that Na-23 magnetic resonance imaging could have utility in assessing the role of tissue Na+ storage for cardiovascular morbidity and mortality in longitudinal studies. (Hypertension. 2013;61:635-640.) circle Online Data Supplement