Effect of betamethasone on pressure-volume relationship of fetal rhesus monkey lung.
Effect of betamethasone on pressure-volume relationship of fetal rhesus monkey lung.
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倍他米松对恒河猴胎肺压力-容积关系的影响。
DOI：
10.1152/jappl.1979.47.2.377
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
A. Palmer
中科院分区：
文献类型：
--
作者：
W. Mitzner;John W.C. Johnson;Rachel Scott;W. London;A. Palmer
我们研究了糖皮质激素给药后胎肺成熟的加速。用倍他米松处理恒河猴胎肺，测得充气-充盈压力-容积曲线。随着空气填充，给药动物的总肺容量（ml空气/g，40 cmH 2 O）显著增加。通过将曲线归一化并将体积绘制为最大体积的百分比，我们检查了放气曲线的形状，这是表面活性剂活性的常用功能测量。我们发现对照组和类固醇治疗组动物之间的形状几乎没有差异。在盐水填充的情况下，肺容量也有类似的增加。由于表面张力对生理盐水压力-容积曲线的影响可以忽略不计，我们得出结论，糖皮质激素对胎儿肺的主要功能影响可能不是表面力的改变。相反，糖皮质激素似乎通过结构变化增加肺顺应性来加速成熟，这种结构变化允许肺包含更多的空气以获得相等的经尿道压力或压力变化。这可以通过增加已经充气的肺泡的扩张性或通过招募新的单位来实现。
We have investigated the acceleration of fetal lung maturity following glucocorticoid administration. Air-filling of saline-filling pressure-volume curves were obtained on fetal rhesus monkey lungs after treatment with betamethasone. With air filling there was a marked increase in the total lung capacity (ml air/g at 40 cmH2O) in the treated animals. By normalizing the curves and plotting volume as a percent maximal volume, we examined the shape of deflation curves, a common functional measure of surfactant activity. We found little difference in the shapes between control and steroid-treated animals. With saline filling there was also a similar increase in the lung capacity. As surface tension has a negligible effect on saline pressure-volume curves, we conclude that the primary functional effect of glucocorticoids on the fetal lung may not be an alteration of surface forces. Rather the glucocorticoids seem to accelerate maturity more by increasing lung compliance through structural changes that allow the lung to contain more air for equivalent transpulmonary pressures or pressure changes. This may occur either by increasing the distensibility of already inflatable alveoli or by recruiting new units.