Obesity reduces the bioavailability of nitric oxide in juveniles
Obesity reduces the bioavailability of nitric oxide in juveniles
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DOI：
10.1038/sj.ijo.0803795
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发表时间：
2008-05-01
影响因子：
4.9
通讯作者：
Wilders-Truschnig, M.
中科院分区：
文献类型：
--
作者：
Gruber, H-J;Mayer, C.;Wilders-Truschnig, M.
目的：越来越多的证据表明，一氧化氮（NO）与肥胖及其临床后果如心血管疾病、高血压和糖尿病密切相关。我们推测NO已经参与了青少年肥胖的病理生理学。我们在这里确定了NO的作用，其代谢产物精氨酸和瓜氨酸在肥胖和正常体重的children.Design：我们调查了57肥胖和57正常体重的年龄和性别匹配的青少年。各种临床参数以及身体测量和内膜中层厚度determined.Results：肥胖青少年揭示了非常显着的改变，在NO通路。与正常体重的青少年相比，肥胖青少年的NOX和瓜氨酸减少，并与体重呈负相关。精氨酸在肥胖青少年中增加，并与体重呈正相关。我们发现一氧化氮和氧化低密度脂蛋白之间存在显着的负相关性。γ-氨基丁酸（GABA）分析显示与NO途径相关，因为NOX和瓜氨酸与GABA呈负相关，而精氨酸则呈正相关。结论：我们在这里表明，NO及其代谢产物精氨酸和瓜氨酸已经参与了青少年肥胖症，这可能有助于通过降低NO的生物利用度来促进动脉粥样硬化的形成。我们确定GABA作为肥胖相关的NO减少机制中的新参数。
Objective: There is growing evidence that nitric oxide (NO) is critically involved in obesity and its clinical consequences like cardiovascular disease, hypertension and diabetes. We hypothesize that NO is already involved in the pathophysiology of juvenile obesity. We here determined the role of NO, its metabolites arginine and citrulline in obese and normal weight children.Design: We investigated 57 obese and 57 normal weight age- and gender-matched juveniles. Various clinical parameters as well as body measurements and intima media thickness were determined.Results: Obese juveniles revealed highly significant alterations in the NO pathway. NOX and citrulline were decreased in obese compared to normal weight juveniles and negatively correlated with body weight. Arginine was increased in obese juveniles and positively correlated with body weight. We found a significant negative correlation between NOX and oxidized low-density lipoprotein. Analysis of gamma-aminobutyric acid (GABA) revealed correlations with the NO pathway as NOX and citrulline were negatively correlated with GABA and arginine showed a positive correlation.Conclusion: We show here that NO and its metabolites arginine and citrulline are already involved in juvenile obesity that may contribute to atherogenesis via reduced bioavailability of NO. Moreover, we identify GABA as a new parameter in the mechanism of obesity-related NO reduction.