Determination of diabetic retinopathy prevalence and associated risk factors in Chinese diabetic and pre-diabetic subjects: Shanghai diabetic complications study
Determination of diabetic retinopathy prevalence and associated risk factors in Chinese diabetic and pre-diabetic subjects: Shanghai diabetic complications study
复制标题
中国糖尿病和糖尿病前期受试者糖尿病视网膜病变患病率及相关危险因素的测定：上海糖尿病并发症研究
DOI：
10.1002/dmrr.1307
复制
发表时间：
2012-03-01
影响因子：
8
通讯作者：
Jia, Weiping
中科院分区：
文献类型：
--
作者：
Pang, Can;Jia, Lili;Jia, Weiping
背景糖尿病视网膜病变（又称糖调节受损）在中国糖尿病前期人群中的患病率尚未得到充分研究。因此，我们调查的患病率和危险因素与视网膜病变的糖尿病和糖尿病前期受试者从中国community.Methods共招募了3736名中国受试者在上海的城市社区。根据75 g口服葡萄糖耐量试验，将参与者分为正常葡萄糖耐量、糖调节受损（IGR）和糖尿病。结果糖尿病视网膜病变的患病率为9.4%，糖调节受损组为2.5%。在IGR受试者中，在年龄和性别调整后，高血压（比值比：3.54，p = 0.028），包括收缩压和舒张压升高和肥胖（比值比：3.53，p = 0.028）与糖尿病视网膜病变显著相关。与糖尿病视网膜病变相关的因素包括糖尿病病程、血糖水平、糖化血红蛋白水平和蛋白尿。糖尿病视网膜病变与空腹血糖显着相关，而在新诊断的受试者，糖尿病神经病变密切相关，餐后血糖。结论高血压是糖尿病视网膜病变的一个强有力的危险因素。在糖尿病前期受试者中，糖尿病视网膜病变也与高血压和肥胖相关。版权所有（C）2011约翰威利父子有限公司
Background The prevalence of diabetic retinopathy is not well studied in the Chinese pre-diabetic population, also known as impaired glucose regulation. Hence, we investigated the prevalence of and risk factors associated with retinopathy in diabetic and pre-diabetic subjects from Chinese communities.Methods A total of 3736 Chinese subjects were recruited from urban communities in Shanghai. The participants were classified as normal glucose tolerance, impaired glucose regulation (IGR) and diabetes based on the 75 g oral glucose tolerance test. The levels of diabetic retinopathy (DR) were assessed with non-mydriatic retinal photographs according to the Diabetic Retinopathy Disease Severity Scale.Results The prevalence of diabetic retinopathy in patients with diabetes and impaired glucose regulation subjects was 9.4% and 2.5%, respectively. In subjects with IGR, hypertension (odds ratio: 3.54, p = 0.028), including elevated systolic and diastolic blood pressure and obesity (odds ratio: 3.53, p = 0.028) were significantly associated with diabetic retinopathy after age and sex adjustments. The factors associated with retinopathy in diabetes included diabetes duration, blood glucose levels, glycated hemoglobin levels, and the presence of albuminuria. Diabetic retinopathy was significantly associated with fasting plasma glucose in known diabetes, whereas in newly-diagnosed subjects, diabetic neuropathy was closely correlated to postprandial plasma glucose.Conclusions Hyperglycemia was a strong risk factor for diabetic retinopathy. In pre-diabetic subjects, diabetic retinopathy was also associated with hypertension and obesity. Copyright (C) 2011 John Wiley & Sons, Ltd.