A Multicentre Year-long Randomised Controlled Trial of Exercise Training Targeting Physical Functioning in Men with Prostate Cancer Previously Treated with Androgen Suppression and Radiation from TROG 03.04 RADAR
A Multicentre Year-long Randomised Controlled Trial of Exercise Training Targeting Physical Functioning in Men with Prostate Cancer Previously Treated with Androgen Suppression and Radiation from TROG 03.04 RADAR
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DOI：
10.1016/j.eururo.2013.09.041
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发表时间：
2014-05-01
期刊：
影响因子：
23.4
通讯作者：
Newton, Robert U.
中科院分区：
文献类型：
--
作者：
Galvao, Daniel A.;Spry, Nigel;Newton, Robert U.
背景资料：长期的前列腺癌（PCa）幸存者患合并症和身体失调的风险增加。目的：确定一项为期一年的随机对照试验的有效性，该试验对诊断后5年以上的PCa幸存者进行运动训练，以改善其身体功能。设计、设置和参与者：在2010年至2011年期间，来自跨塔斯曼放射肿瘤学小组的100名长期PCa幸存者03.04随机雄激素去甲肾上腺素和既往接受过雄激素治疗的放疗-剥夺治疗和放射治疗被随机分配到6个月的监督运动，随后是6个月的家庭维护计划（n = 50）或12个月的关于体育活动的印刷教育材料（n = 50），干预措施：监督阻力和有氧运动或印刷有关身体活动的教育材料。结果测量和统计分析：主要终点是400米步行作为心血管健康的测量。次要终点是身体功能、患者报告的结果、肌肉力量、身体成分和生物标志物。协方差分析用于比较根据基线值调整后的6个月和12个月组的结局。结果和局限性：接受监督锻炼的参与者在6个月时心肺适能表现有所改善（-19秒[p = 0.029]）和12个月（-13秒[p = 0.028]），12个月期间的下半身身体功能更好（p <0.01）。有监督的运动还改善了6个月（p = 0.006）和12个月（p = 0.002）时自我报告的身体功能，6个月时的骨骼肌（p = 0.019），以及6个月和12个月时的肌肉力量的客观测量（p <0.050）。局限性包括有限的参与者进行身体成分评估，没有盲目组分配的身体功能的措施，并列入功能良好的individuals.Conclusions：在长期PCa幸存者的监督运动训练是更有效的比体育活动的教育材料，增加心肺功能，身体功能，肌肉力量，自我报告的身体功能在6个月。重要的是，这些好处是保持在长期与家庭为基础的方案，在12个月随访。(C)2013年由Elsevier B.V.代表欧洲泌尿外科协会发表。
Background: Long-term prostate cancer (PCa) survivors are at increased risk for comorbidities and physical deconditioning.Objective: To determine the effectiveness of a year-long randomised controlled trial of exercise training in PCa survivors >5 yr postdiagnosis on physical functioning.Design, setting, and participants: Between 2010 and 2011, 100 long-term PCa survivors from Trans-Tasman Radiation Oncology Group 03.04 Randomised Androgen Deprivation and Radiotherapy previously treated with androgen-deprivation therapy and radiation therapy were randomly assigned to 6 mo of supervised exercise followed by 6 mo of a home-based maintenance programme (n = 50) or printed educational material about physical activity (n = 50) for 12 mo across 13 university-affiliated exercise clinics in Australia and New Zealand.Intervention: Supervised resistance and aerobic exercise or printed educational material about physical activity.Outcome measurements and statistical analysis: The primary end point was a 400-m walk as a measure of cardiovascular fitness. Secondary end points were physical function, patient-reported outcomes, muscle strength, body composition, and biomarkers. Analysis of covariance was used to compare outcomes for groups at 6 and 12 mo adjusted for baseline values.Results and limitations: Participants undergoing supervised exercise showed improvement in cardiorespiratory fitness performance at 6 mo (-19 s [p = 0.029]) and 12 mo (-13 s [p = 0.028]) and better lower-body physical function across the 12-mo period (p < 0.01). Supervised exercise also improved self-reported physical functioning at 6 (p = .006) and 12 mo (p = 0.002), appendicular skeletal muscle at 6 mo (p = 0.019), and objective measures of muscle strength at 6 and 12 mo (p < 0.050). Limitations included the restricted number of participants undertaking body composition assessment, no blinding to group assignment for physical functioning measures, and inclusion of well-functioning individuals.Conclusions: Supervised exercise training in long-term PCa survivors is more effective than physical activity educational material for increasing cardiorespiratory fitness, physical function, muscle strength, and self-reported physical functioning at 6 mo. Importantly, these benefits were maintained in the long term with a home-based programme with follow-up at 12 mo. (C) 2013 Published by Elsevier B.V. on behalf of European Association of Urology.