The comparison of designs for sequential clinical trials with covariate information
The comparison of designs for sequential clinical trials with covariate information
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DOI：
10.1111/1467-985x.00564
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发表时间：
2002-01-01
影响因子：
2
通讯作者：
Atkinson, AC
中科院分区：
文献类型：
--
作者：
Atkinson, AC
本文研究了临床试验中治疗顺序分配的有偏硬币型随机化规则的比较方法。一个重要的特征是损失，它度量由于随机化引起的不平衡而导致的参数估计方差的增加。另一个重要的特征是选择偏差，测量正确猜测下一次分配哪种治疗的概率。这两个措施的结合导致可容许的设计的说明。模拟提供了设计行为的清晰曲线，并使区分好的设计和不太好的设计成为可能。
The paper develops methods for the comparison of randomized rules of the biased coin type for the sequential allocation of treatments in a clinical trial. One important characteristic is the loss, which measures the increase in the variance of parameter estimates due to the imbalance caused by randomization. The other important characteristic is the selection bias measuring the probability of correctly guessing which treatment is to be allocated next. The combination of these two measures leads to the elucidation of admissible designs. Simulations provide clear plots of the behaviour of the designs and make it possible to distinguish good designs from those which are less good.