Higher-order unimodal olfactory sensory preconditioning in Drosophila.
Higher-order unimodal olfactory sensory preconditioning in Drosophila.
复制标题
DOI：
10.7554/elife.79107
复制
发表时间：
2022-09-21
期刊：
影响因子：
7.7
通讯作者：
Cervantes-Sandoval I
中科院分区：
文献类型：
--
作者：
Martinez-Cervantes J;Shah P;Phan A;Cervantes-Sandoval I
学习和记忆存储是一个复杂的过程，事实证明，这一过程具有挑战性。很可能，在本质上，强化经验的教育价值是后天获得的，而不是与生俱来的。看似中性的刺激之间的联系增加了创造有意义联系的可能性的范围，并增加了时刻体验的预测力。在这里，我们报告了果蝇嗅觉单峰感觉预适应的生理和行为证据。我们发现，在其中一种气味(S1)与电击相关之前呈现一对气味(S1和S2)，不仅会引起对训练过的气味(S1)的条件反应，而且会引起对先前与之配对的气味(S2)的条件反应。即使S2气味从未与令人厌恶的刺激相邻呈现，这种情况也会发生。此外，我们还表明，抑制小G蛋白rac1，一种已知的遗忘调节因子，有助于S1/S2气味之间的联系。这些结果表明，果蝇可以根据气味之间先前的关联结构来推断嗅觉刺激的值，而对rac1的抑制延长了嗅觉“感觉缓冲区”的时间窗口，允许在顺序呈现的气味之间建立联系。
Learning and memory storage is a complex process that has proven challenging to tackle. It is likely that, in nature, the instructive value of reinforcing experiences is acquired rather than innate. The association between seemingly neutral stimuli increases the gamut of possibilities to create meaningful associations and the predictive power of moment-by-moment experiences. Here, we report physiological and behavioral evidence of olfactory unimodal sensory preconditioning in fruit flies. We show that the presentation of a pair of odors (S1 and S2) before one of them (S1) is associated with electric shocks elicits a conditional response not only to the trained odor (S1) but to the odor previously paired with it (S2). This occurs even if the S2 odor was never presented in contiguity with the aversive stimulus. In addition, we show that inhibition of the small G protein Rac1, a known forgetting regulator, facilitates the association between S1/S2 odors. These results indicate that flies can infer value to olfactory stimuli based on the previous associative structure between odors, and that inhibition of Rac1 lengthens the time window of the olfactory ‘sensory buffer’, allowing the establishment of associations between odors presented in sequence.