Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients
Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients
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DOI：
10.1097/01.ccm.0000254340.91644.b2
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发表时间：
2007-02-01
影响因子：
8.8
通讯作者：
Douglas, Ivor S.
中科院分区：
文献类型：
--
作者：
O'Brien, James M., Jr.;Lu, Bo;Douglas, Ivor S.
Objective.确定酒精依赖（酒精中毒未缓解和/或酒精戒断）与脓毒症、脓毒性休克和重症监护室（ICU）患者住院死亡率之间的关系。设计：回顾性队列研究。患者：患者包括1999年1月1日至2004年12月31日在丹佛健康医疗中心住院的11，651名成人，ICU日>= 1。无。测量和主要结果。在数据集中出现的首次入院（n = 9，981）中，1，222人（12.2%）的诊断与酒精依赖一致。这些患者的败血症发生率较高（12.9%对7.6%，p
Objective. To determine the association between alcohol dependence (alcoholism not in remission and/or alcohol withdrawal) and sepsis, septic shock, and hospital mortality among intensive care unit (ICU) patients.Design: Retrospective cohort study.Setting. Two ICUs in an urban hospital.Patients: Patients included 11,651 adult admissions to Denver Health Medical Center from January 1, 1999, to December 31, 2004, with >= 1 ICU day.Interventions. None.Measurements and Main Results. Of first admissions appearing in the data set (n = 9,981), 1,222 (12.2%) had a diagnosis consistent with alcohol dependence. These patients had higher rates of sepsis (12.9% vs. 7.6%, p