Ancient Migratory Events in the Middle East: New Clues from the Y-Chromosome Variation of Modern Iranians
Ancient Migratory Events in the Middle East: New Clues from the Y-Chromosome Variation of Modern Iranians
复制标题
DOI：
10.1371/journal.pone.0041252
复制
发表时间：
2012-07-18
期刊：
影响因子：
3.7
通讯作者：
Semino, Ornella
中科院分区：
文献类型：
--
作者：
Grugni, Viola;Battaglia, Vincenza;Semino, Ornella
伊朗境内的高分辨率Y染色体单倍型群多样化的知识提供了重要的地理背景下传播和划分的男性血统在中东和亚洲西南部。目前，伊朗人口的特点是不同族裔群体的混合，他们说各种印度-伊朗语、闪米特语和突厥语。尽管有这些特征，但只有少数研究调查了伊朗基因库的多民族成分。在这项调查中，来自伊朗14个省的15个民族的938名伊朗男性DNA进行了84个Y染色体双等位基因标记和10个STR分析。结果表明，该地区的古地理背景是由J2 a亚支组成的，但各亚支的外部贡献不同。主要单倍型群的地理分布允许确定冰后期和新石器时代向欧亚大陆西部的扩张，但也允许确定最近从欧亚大陆西部（R1 b-L23）、中亚（Q-M25）、小亚细亚（J2 a-M92）和美索不达米亚南部（J1-Page 08）向伊朗地区的移动。尽管存在着重要的地理障碍（扎格罗斯山脉和阿尔博尔兹山脉以及卡维尔沙漠和卢特沙漠），可能限制了基因流动，但AMOVA分析表明，除了地理之外，语言在塑造当今伊朗的基因库方面发挥了重要作用。总的来说，这项研究提供了一个画像的Y染色体变异在伊朗，有用的描绘更全面的历史，该地区的人民，以及重建古代的迁移路线。此外，我们的研究结果证明了伊朗高原作为文化和遗传不同人群之间基因流的来源和接受者的重要作用。
Knowledge of high resolution Y-chromosome haplogroup diversification within Iran provides important geographic context regarding the spread and compartmentalization of male lineages in the Middle East and southwestern Asia. At present, the Iranian population is characterized by an extraordinary mix of different ethnic groups speaking a variety of Indo-Iranian, Semitic and Turkic languages. Despite these features, only few studies have investigated the multiethnic components of the Iranian gene pool. In this survey 938 Iranian male DNAs belonging to 15 ethnic groups from 14 Iranian provinces were analyzed for 84 Y-chromosome biallelic markers and 10 STRs. The results show an autochthonous but non-homogeneous ancient background mainly composed by J2a sub-clades with different external contributions. The phylogeography of the main haplogroups allowed identifying post-glacial and Neolithic expansions toward western Eurasia but also recent movements towards the Iranian region from western Eurasia (R1b-L23), Central Asia (Q-M25), Asia Minor (J2a-M92) and southern Mesopotamia (J1-Page08). In spite of the presence of important geographic barriers (Zagros and Alborz mountain ranges, and the Dasht-e Kavir and Dash-e Lut deserts) which may have limited gene flow, AMOVA analysis revealed that language, in addition to geography, has played an important role in shaping the nowadays Iranian gene pool. Overall, this study provides a portrait of the Y-chromosomal variation in Iran, useful for depicting a more comprehensive history of the peoples of this area as well as for reconstructing ancient migration routes. In addition, our results evidence the important role of the Iranian plateau as source and recipient of gene flow between culturally and genetically distinct populations.