Myosins in cell junctions.
Myosins in cell junctions.
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DOI：
10.4161/bioa.21791
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Cheney RE
中科院分区：
文献类型：
--
作者：
Liu KC;Cheney RE
细胞-细胞连接的发展是后生动物进化的一个基本步骤，人类的健康取决于细胞连接的形成和功能。虽然人们早就知道肌动蛋白和常规肌凝蛋白在细胞连接中起重要作用，但研究已经开始揭示不同形式的常规肌凝蛋白的具体功能。令人兴奋的新数据还显示，越来越多的非常规肌凝蛋白在细胞连接中起着重要作用。实验表明，细胞连接作为机械传感器也为理解肌凝蛋白的功能和它们施加的力提供了新的动力。在这篇综述中，我们将总结肌凝蛋白在细胞连接中的作用的最新进展。
The development of cell-cell junctions was a fundamental step in metazoan evolution, and human health depends on the formation and function of cell junctions. Although it has long been known that actin and conventional myosin have important roles in cell junctions, research has begun to reveal the specific functions of the different forms of conventional myosin. Exciting new data also reveals that a growing number of unconventional myosins have important roles in cell junctions. Experiments showing that cell junctions act as mechanosensors have also provided new impetus to understand the functions of myosins and the forces they exert. In this review we will summarize recent developments on the roles of myosins in cell junctions.