ANAPHYLAXIS TO MEASLES, MUMPS, AND RUBELLA VACCINE MEDIATED BY IGE TO GELATIN
ANAPHYLAXIS TO MEASLES, MUMPS, AND RUBELLA VACCINE MEDIATED BY IGE TO GELATIN
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DOI：
10.1016/0091-6749(93)90344-f
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发表时间：
1993-04-01
影响因子：
14.2
通讯作者：
YUNGINGER, JW
中科院分区：
文献类型：
--
作者：
KELSO, JM;JONES, RT;YUNGINGER, JW
工作背景：对麻疹、腮腺炎和风疹（MMR）疫苗的过敏反应很罕见;有些是由于对微量鸡蛋蛋白过敏。我们报告一位十七岁的女性，对麻腮风疫苗有过敏反应。在15个月大时接种MMR初次疫苗没有发生任何事件。她对鸡蛋不过敏，但吃了明胶后，耳朵和喉咙瘙痒和舌头肿胀。方法和结果：MMR疫苗与明胶1：10稀释液的皮肤点刺试验阳性，而鸡蛋点刺试验阴性。通过免疫测定，她的血清IgE抗体升高MMR疫苗和明胶，但不分离的MMR抗原。IgE与明胶载体的结合可以通过添加不仅MMR疫苗而且来自各种动物来源的明胶以剂量依赖性方式被抑制。免疫印迹证实了IgE抗体的存在，多个明胶成分，以及MMR疫苗components.Conclusions：我们的结论是，病人有过敏敏感性明胶，她的过敏反应MMR疫苗是由明胶成分。这种敏感性可以解释其他MMR过敏反应病例。
Background: Allergic reactions to measles, mumps, and rubella (MMR) vaccine are rare; some have been attributed to allergy to trace quantities of egg proteins. We report a 17-year-old female who had an anaphylactic reaction to MMR vaccine. A primary vaccination with MMR at age 15 months had been uneventful. She is not allergic to eggs; however, ear and throat pruritus and tongue swelling develop after she eats gelatin. MMR vaccine contains gelatin as a stabilizer.Methods and Results: Prick skin tests were positive to 1:10 wt/vol dilutions of MMR vaccine and gelatin but negative to egg. By immunoassay, her serum IgE antibodies were elevated to both MMR vaccine and gelatin, but not to isolated MMR antigens. IgE binding to the gelatin carrier could be inhibited in a dose-dependent fashion by addition of not only MMR vaccine but also gelatin from a variety of animal sources. Immunoblotting confirmed the presence of IgE antibodies to multiple gelatin components as well as to MMR vaccine components.Conclusions: We conclude that the patient has an anaphylactic sensitivity to gelatin, and that her anaphylaxis to MMR vaccine was caused by the gelatin component. This sensitivity may explain other cases of MMR anaphylaxis.