Phytotoxic and antifungal metabolites from Curvularia sp FH01 isolated from the gut of Atractomorpha sinensis
Phytotoxic and antifungal metabolites from Curvularia sp FH01 isolated from the gut of Atractomorpha sinensis
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DOI：
10.1016/j.biortech.2010.10.028
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发表时间：
2011-02-01
影响因子：
11.4
通讯作者：
Zheng, Jiang-yan
中科院分区：
文献类型：
--
作者：
Zhang, Ying-lao;Kong, Li-chun;Zheng, Jiang-yan
从中华无烟菌肠道真菌曲霉菌（Curvularia sp. FH01）中分离到两种主要的植物毒性和抗真菌活性物质邻苯二甲酸丁基异丁基酯(1)和根尖素(2)。通过光谱分析确定了分离代谢物的结构。代谢物1和2对刺青藻自由基生长具有显著的抑制作用，其IC（50）值分别为61.9和5.9 μ g/mL，与阳性对照2,4-二氯苯氧乙酸（2.0 μ g/mL）相当。抑菌试验结果表明，化合物2对稻瘟病病菌（Magnaporthe grisea， IC(50) = 16.3 μ g/mL）和马利病菌（Valsa mali， IC(50) = 18.2 μ g/mL）具有较强的抑菌活性。本研究结果表明，真菌FH01的生物活性特性可归功于其主要成分邻苯二甲酸丁基异丁基酯和自由基素，这两种物质都具有作为除草剂和杀菌剂的潜力。(C) 2010 Elsevier Ltd.版权所有。
Two main phytotoxic and antifungal phthalic acid butyl isobutyl ester (1) and radicinin (2) were isolated from the culture of Curvularia sp. FH01, a fungus residing in the Atractomorpha sinensis gut. The structures of isolated metabolites were established on the basis of spectral analysis. Metabolites 1 and 2 exhibited significant phytotoxic activity against the radical growth of Echinochloa crusgalli with their IC(50) values of 61.9 and 5.9 mu g/mL, respectively, which were comparable to that 2,4-dichlorophenoxyacetic acid (2.0 mu g/mL) used as a positive control. The antifungal test results showed that compound 2 possessed strong antifungal activity against Magnaporthe grisea (IC(50) = 16.3 mu g/mL) and Valsa mali (IC(50) = 18.2 mu g/mL). The findings of the present study suggest that bioactive properties of the fungus FH01 can be attributed to its major components, phthalic acid butyl isobutyl ester and radicinin, and both agents have a potential to be used as herbicide and fungicide. (C) 2010 Elsevier Ltd. All rights reserved.