The nanopore mass spectrometer
The nanopore mass spectrometer
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DOI：
10.1063/1.4986043
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发表时间：
2017-11-01
影响因子：
1.6
通讯作者：
Stein, Derek
中科院分区：
文献类型：
--
作者：
Bush, Joseph;Maulbetsch, William;Stein, Derek
我们报告的质谱仪的设计具有离子源，提供离子直接进入高真空从液体内的毛细管与亚微米直径的尖端。水和甲酰胺的表面张力足以维持尖端处具有高真空的稳定界面，并且来自界面的气体负载可以忽略不计，即使在电喷雾期间也是如此。这些条件提高了差动泵送系统的通常要求。没有背景气体也开辟了设计离子光学器件来收集和聚焦离子以实现高的整体传输和检测效率的可能性。我们描述的操作和性能的仪器和目前的质谱从溶液中的盐离子和DNA碱基在甲酰胺和盐离子在水中。光谱显示单电荷溶质离子与少量溶剂分子成簇。出版社：AIP Publishing
We report the design of a mass spectrometer featuring an ion source that delivers ions directly into high vacuum from liquid inside a capillary with a sub-micrometer-diameter tip. The surface tension of water and formamide is sufficient to maintain a stable interface with high vacuum at the tip, and the gas load from the interface is negligible, even during electrospray. These conditions lifted the usual requirement of a differentially pumped system. The absence of a background gas also opened up the possibility of designing ion optics to collect and focus ions in order to achieve high overall transmission and detection efficiencies. We describe the operation and performance of the instrument and present mass spectra from solutions of salt ions and DNA bases in formamide and salt ions in water. The spectra show singly charged solute ions clustered with a small number of solvent molecules. Published by AIP Publishing.