Emergence in Brazil of methicillin-resistant Staphylococcus aureus isolates carrying SCCmecIV that are related genetically to the USA800 clone
Emergence in Brazil of methicillin-resistant Staphylococcus aureus isolates carrying SCCmecIV that are related genetically to the USA800 clone
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DOI：
10.1111/j.1469-0691.2007.01830.x
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发表时间：
2007-12-01
影响因子：
14.2
通讯作者：
Figueiredo, A. M. S.
中科院分区：
文献类型：
--
作者：
de Miranda, O. P.;Silva-Carvalho, M. C.;Figueiredo, A. M. S.
非多重耐药耐甲氧西林金黄色葡萄球菌（nMMRSA）引起的医院感染的发病率在全球范围内不断增加。本研究对从巴西两个城市的医院获得的nMMMRSA分离株进行基因型分析。医院分离株的脉冲场凝胶电泳（PFGE）图谱与USA 100（ST 5-SCCmecII）和USA 800（ST 5-SCCmecIV）菌株相似，分别与纽约/日本和儿科克隆相关。携带SCCmecIV和分类的多位点序列分型（MLST）的一个代表，这PFGE模式在克隆复合体5（CC 5）证实了巴西分离株与USA 800的遗传关系。USA 800相关的巴西分离株是巴西受损成人和老年患者严重医院感染的原因。更高的生长速度，在惰性聚苯乙烯表面形成生物膜的能力，以及egc基因座的存在，可能至少部分地导致了这些生物体作为全球医院病原体的适应性。
An increasing incidence of nosocomial infections caused by non-multiresistant methicillin-resistant Staphylococcus aureus (nMMRSA) has been reported worldwide. The present study genotyped nMMRSA isolates obtained from hospitals in two cities in Brazil. The hospital isolates displayed pulsed-field gel electrophoresis (PFGE) patterns that were similar to those of the USA100 (ST5-SCCmecII) and USA800 (ST5-SCCmecIV) strains, which are related to the New York/Japan and paediatric clones, respectively. Carriage of SCCmecIV and the classification by multilocus sequence typing (MLST) of a representative of this PFGE pattern in clonal complex 5 (CC5) confirmed the genetic relationship of the Brazilian isolates with USA800. The USA800-related Brazilian isolates were responsible for severe nosocomial infections in compromised adults and elderly patients in Brazil. A higher growth rate, an ability to form biofilm on inert polystyrene surfaces and the presence of the egc locus may have contributed, at least in part, to the fitness of these organisms as global nosocomial pathogens.