Research Roadmap for Tuberculosis Transmission Science: Where Do We Go From Here and How Will We Know When We're There?
Research Roadmap for Tuberculosis Transmission Science: Where Do We Go From Here and How Will We Know When We're There?
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DOI：
10.1093/infdis/jix353
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发表时间：
2017-11-03
期刊：
影响因子：
--
通讯作者：
Shah NS
中科院分区：
文献类型：
--
作者：
Auld SC;Kasmar AG;Dowdy DW;Mathema B;Gandhi NR;Churchyard GJ;Rustomjee R;Shah NS
结核病的高传播率正在推动全球结核病的持续流行，迫切需要进行以了解并最终阻止传播为重点的研究。结核病和人体免疫缺陷病毒（艾滋病毒）共同流行的情况持续存在，世界部分地区耐药结核病的发病率不断上升，这进一步增加了这项工作的紧迫性。这项研究的成功将需要结核病科学家、临床医生、项目和资助者的协调一致的多学科努力，并且必须跨越从生物医学科学到社会科学、公共卫生、流行病学、成本效益分析和运筹学的研究范围。结核病在病人个人和社区之间的异质性对阻断传播的努力构成了重大挑战。因此，阻止传播的有效干预措施可能需要结合各种方法，这些方法在不同的流行病学背景下会有所不同。本研究路线图总结了我们目前对传播理解的主要差距，如本系列前面的文章所述。我们还希望，这将是全球结核病界的一个行动呼吁，对结核病传播科学作出持续的承诺。今天停止传播是明天消除结核病道路上的重要一步。
High rates of tuberculosis transmission are driving the ongoing global tuberculosis epidemic, and there is a pressing need for research focused on understanding and, ultimately, halting transmission. The ongoing tuberculosis–human immunodeficiency virus (HIV) coepidemic and rising rates of drug-resistant tuberculosis in parts of the world add further urgency to this work. Success in this research will require a concerted, multidisciplinary effort on the part of tuberculosis scientists, clinicians, programs, and funders and must span the research spectrum from biomedical sciences to the social sciences, public health, epidemiology, cost-effectiveness analyses, and operations research. Heterogeneity of tuberculosis disease, both among individual patients and among communities, poses a substantial challenge to efforts to interrupt transmission. As such, it is likely that effective interventions to stop transmission will require a combination of approaches that will vary across different epidemiologic settings. This research roadmap summarizes key gaps in our current understanding of transmission, as laid out in the preceding articles in this series. We also hope that it will be a call to action for the global tuberculosis community to make a sustained commitment to tuberculosis transmission science. Halting transmission today is an essential step on the path to end tuberculosis tomorrow.
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DOI：
10.1111/tmi.12459
发表时间：
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期刊：
Tropical medicine & international health : TM & IH
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