Sequential expression of murine homeo box genes during F9 EC cell differentiation.
Sequential expression of murine homeo box genes during F9 EC cell differentiation.
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DOI：
10.1002/j.1460-2075.1986.tb04486.x
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发表时间：
1986-09
期刊：
影响因子：
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通讯作者：
G. Breier;M. Bucan;U. Francke;A. Colberg-Poley;P. Gruss
中科院分区：
文献类型：
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作者：
G. Breier;M. Bucan;U. Francke;A. Colberg-Poley;P. Gruss
我们已经分离并鉴定了一种以前不为人知的鼠类homo box家族成员。这个新的基因座m31位于第15号染色体上，与果蝇同源基因Antp的序列更相似，而不是其他已知的小鼠同源盒。我们发现该基因编码2.7 kb mRNA，在小鼠胚胎发生和F9畸胎瘤细胞向壁内胚层细胞分化过程中表达。转录本出现在分化过程的后期，并且在F9细胞开始表达组织特异性标记物和另一个小鼠同源盒基因m6表达减少的时候最为丰富。
We have isolated and characterized a previously unknown member of the murine homeo box family. The new locus, m31, is located on chromosome 15 and is more homologous to sequences contained in the Drosophila homeotic gene, Antp, than to any other known murine homeo box. We show that this gene encodes a 2.7 kb mRNA which is expressed during mouse embryogenesis and during differentiation of F9 teratocarcinoma cells into parietal endoderm cells. The transcript appears late in this differentiation process and is most abundant at a time when the F9 cells begin to express tissue‐specific markers and the expression of another murine homeo box gene, m6, has decreased.