Non-Gaussian model-based diffusion-weighted imaging of oral squamous cell carcinoma: associations with Ki-67 proliferation status
Non-Gaussian model-based diffusion-weighted imaging of oral squamous cell carcinoma: associations with Ki-67 proliferation status
复制标题
基于非高斯模型的口腔鳞状细胞癌扩散加权成像：与 Ki-67 增殖状态的关联
DOI：
10.1007/s11282-023-00682-x
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发表时间：
2023
期刊：
影响因子：
2.2
通讯作者：
Minowa Kazuyuki
中科院分区：
文献类型：
--
作者：
Shima Tomoka;Fujima Noriyuki;Yamano Shigeru;Kameda Hiroyuki;Suzuka Masaaki;Takeuchi Akiko;Kinoshita Yurika;Iwai Nanami;Kudo Kohsuke;Minowa Kazuyuki
ObjectivesTo探讨口腔鳞状细胞癌（OSCC）患者非高斯模型拟合的弥散加权成像（DWI）参数与Ki-67状态之间的可能相关性。使用6个b值（0-2500）进行DWI。采用4种扩散拟合模型计算扩散相关参数峰度值（K）、峰度校正扩散系数（DK）、扩散异质性（α）、分布扩散系数（DDC）、慢扩散系数（Dslow）和表观扩散系数（ADC）。Ki-67状态分为低（Ki-67百分比评分< 20%）、中（20-50%）或高（> 50%）。对各非高斯扩散模型参数与Ki-67分级进行Kruskal-Wallis检验。在Ki-67状态的三个水平之间（K、ADC、Dk、DDC和Dslow）显示统计学显著差异（K：p= 0.020，ADC：p= 0.012，Dk：p= 0.027，DDC：p= 0.007和Dslow：p= 0.026）。结论几个非高斯扩散模型参数和ADC值与Ki-67显著相关。67状态，并有潜力作为有前途的预后生物标志物在口腔鳞癌患者。
ObjectivesTo investigate possible associations between diffusion-weighted imaging (DWI) parameters derived from a non-Gaussian model fitting and Ki-67 status in patients with oral squamous cell carcinoma (OSCC).MethodsTwenty-four patients with newly diagnosed OSCC were prospectively recruited. DWI was performed using sixb-values (0–2500). The diffusion-related parameters of kurtosis value (K), kurtosis-corrected diffusion coefficient (DK), diffusion heterogeneity (α), distributed diffusion coefficient (DDC), slow diffusion coefficient (Dslow), and apparent diffusion coefficient (ADC) were calculated from four diffusion fitting models. Ki-67 status was categorized as low (Ki-67 percentage score < 20%), middle (20–50%), or high (> 50%). Kruskal–Wallis tests were performed between each non-Gaussian diffusion model parameters and Ki-67 grade.ResultsThe Kruskal–Wallis tests revealed that multiple parameters (K, ADC, Dk, DDC and Dslow) showed statistically significant differences between the three levels of Ki-67 status (K:p= 0.020, ADC:p= 0.012, Dk:p= 0.027, DDC:p= 0.007 and Dslow:p= 0.026).ConclusionsSeveral non-Gaussian diffusion model parameters and ADC values were significantly associated with Ki-67 status and have potential as promising prognostic biomarkers in patients with OSCC.