Three-Dimensional 1060-nm OCT: Choroidal Thickness Maps in Normal Subjects and Improved Posterior Segment Visualization in Cataract Patients
Three-Dimensional 1060-nm OCT: Choroidal Thickness Maps in Normal Subjects and Improved Posterior Segment Visualization in Cataract Patients
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DOI：
10.1167/iovs.10-5196
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发表时间：
2010-10-01
影响因子：
4.4
通讯作者：
Drexler, Wolfgang
中科院分区：
文献类型：
--
作者：
Esmaeelpour, Marieh;Povazay, Boris;Drexler, Wolfgang
目的.通过生成不同年龄、不同屈光不正程度和眼轴长度患者的脉络膜厚度（ChT）图，评估三维（3D）1060 nm OCT的性能和潜在临床作用，并研究白内障分级对OCT视网膜成像质量的影响。对34例（19 ~ 80岁，屈光不正+3 ~-10D）健康人64眼进行眼轴长度（AL）和45 °眼底照相。3D 1060 nm OCT在36度x 36度的视场内进行，轴向分辨率与7 μ m相似，最高可达70帧/秒（512 A扫描/帧）。生成视网膜色素上皮和脉络膜-巩膜界面之间的ChT图并进行统计学分析。另外30只眼（19名受试者），用LOCS III量表评估白内障，用3D 1060 nm OCT和800 nm OCT成像，并定性比较后节的可视化。在64只眼中，ChT图显示厚度随AL增加而减少，中心凹下ChT为315 ± 106 μ m（平均值± SD），与AL呈负相关（R-2 =-0.47，P < 0.001）。AL < 23.39 mm的眼睛的平均ChT图显示，与中心凹下ChT相比，在近似1500 μ m下方的区域ChT增加。AL > 24.5 mm的眼显示较大的变异，ChT上部比后部厚。白内障眼的800 nm OCT图像中有65%的图像信号强度降低，而1060 nm OCT图像中只有10%的图像信号强度降低。3D 1060-nm OCT的成像性能是独特的，产生的图显示了整个视野内ChT的变化，与轴长有关。该成像系统具有可视化新的临床诊断生物标志物的潜力。与800 nm OCT相比，它提供了白内障患者眼后极的上级可视化。（Invest Ophthalmol维斯科学。2010;51：5260-5266）DOI：10.1167/iovs.10-5196
PURPOSE. To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality.METHODS. Axial lengths (ALs) and 45 degrees fundus photographs were acquired from 64 eyes (34 healthy subjects, 19 to 80 years, ametropia +3 to -10 D). 3D 1060-nm OCT was performed over a 36 degrees x 36 degrees field of view with similar to 7-mu m axial resolution and up to 70 frames/s (512 A-scans/frame). ChT maps between retinal pigment epithelium and the choroidal-scleral interface, were generated and statistically analyzed. A further 30 eyes (19 subjects), with cataracts assessed with the LOCS III scale, were imaged with 3D 1060-nm OCT and 800-nm OCT, and visualization of the posterior segment was compared qualitatively.RESULTS. In 64 eyes, ChT maps displayed a thickness decrease with increasing AL. Subfoveal ChT was 315 +/- 106 mu m (mean +/- SD), negatively correlated with AL (R-2 = -0.47, P < 0.001). Averaged ChT maps of eyes with AL < 23.39 mm showed an increased ChT in an area similar to 1500 mu m inferior, compared with subfoveal ChT. Eyes with AL > 24.5 mm showed a larger variation and a thicker ChT superiorly than inferiorly. Reduced signal strength in cataractous eyes was found in 65% of the 800-nm OCT images, but in only 10% of the 1060-nm OCT images.CONCLUSIONS. The imaging performance of 3D 1060-nm OCT is unique, producing maps that show the variation in ChT over the entire field of view, in relation to axial length. This imaging system has the potential of visualizing a novel clinical diagnostic biomarker. Compared with 800-nm OCT, it provides superior visualization of the posterior pole in cataractous eyes. (Invest Ophthalmol Vis Sci. 2010;51:5260-5266) DOI:10.1167/iovs.10-5196