Social status in mice: behavioral, endocrine and immune changes are context dependent
Social status in mice: behavioral, endocrine and immune changes are context dependent
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DOI：
10.1016/s0031-9384(01)00453-x
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发表时间：
2001-06-01
影响因子：
2.9
通讯作者：
Parmigiani, S
中科院分区：
文献类型：
--
作者：
Bartolomucci, A;Palanza, P;Parmigiani, S
本研究旨在探讨社会地位对雄性小鼠内分泌、免疫和行为反应的影响。我们发现，在一组兄弟姐妹饲养的小鼠断奶后，不存在差异的基础皮质酮水平，在旷场试验（OFT）的行为和一系列的免疫参数之间的优势和劣势。这些结果表明，与兄弟姐妹生活在一起，无论是占主导地位还是从属地位的小鼠，都不会有压力。因此，在社会压力研究中，群体居住的兄弟姐妹可以被视为一个有效的控制组。当小鼠受到21天的慢性心理社会应激时，发生了四种类型的社会结果：居民成为主导者，入侵者成为从属者，居民成为从属者，入侵者成为主导者。有趣的是，在OFT中的行为特征显示出状态依赖性效应，居民显性（RD）和入侵者显性（InD）显示出最高的运动和探索活动，而皮质酮水平高于对照组的所有四个类别。此外，在免疫水平上出现了一种环境依赖性效应：居民下属（RS）的脾细胞增殖和IL-4和IL-10的产生减少。其他三个社会等级的小鼠都没有表现出免疫变化。因此，一个人的社会地位的损失似乎是一个有前途的研究领域，以调查心理压力事件的影响。(C)2001 Elsevier Science Inc. All rights reserved.
The aim of the present study was to investigate the effect of social status on the endocrine, immune and behavior response of male mice. We found that in mice reared in a group of siblings since weaning, no difference exists between dominants and subordinates in basal corticosterone level, in behavior in the open-field test (OFT) and in a series of immune parameters. These results suggest that living with siblings is not a stressful condition for either dominant or subordinate mice. Therefore, group-housed siblings can be regarded as a valid control group in social stress studies. When mice were subjected to chronic psychosocial stress for 21 days, four types of social outcome occurred: residents becoming dominants, intruders becoming subordinates, residents becoming subordinates and intruders becoming dominants. Interestingly the behavioral profile in the OFT revealed a status-dependent effect, with resident dominants (RD) and intruder dominants (InD) showing the highest locomotor and exploratory activity, whereas the corticosterone level was higher than control for all four categories. In addition, a context-dependent effect emerged at the immune level: resident subordinates (RS) had a reduced splenocyte proliferation and IL-4 and IL-10 production. Mice in all the other three social ranks showed no immune alterations. Therefore, the loss of an individual's social rank position seems a promising field of study to investigate the psychological impact of stressful events. (C) 2001 Elsevier Science Inc. All rights reserved.