Characterization of ibuprofen as a nontraditional plasticizer of ethyl cellulose
Characterization of ibuprofen as a nontraditional plasticizer of ethyl cellulose
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DOI：
10.1002/jps.10159
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发表时间：
2002-07-01
影响因子：
3.8
通讯作者：
Remon, JP
中科院分区：
文献类型：
--
作者：
De Brabander, C;Van den Mooter, G;Remon, JP
本研究描述了布洛芬（IBP）对热熔挤出乙基纤维素（EC）的塑化性能的表征。使用调制温度差示扫描量热法评价含有0、5、10和20%（w/w）IBP的热熔挤出物的热行为。通过比较，还评价了含有相同浓度的IBP和EC的共蒸发物。这两种方法都产生具有一个玻璃化转变温度的固体溶液，表明药物和聚合物之间的相容性。通过这两种方法制备的固溶体中，随着IBP浓度的增加，玻璃化转变温度出现类似的降低，表明其具有增塑作用。塑化效率与传统使用的增塑剂具有相同的量级。红外光谱进行了更好地了解分子分散体中的化学相互作用，并证实IBP和EC之间存在氢键。总体而言，该研究突出了在热熔挤出过程中IBP对EC的增塑性能。(C)2002 Wiley-Liss，Inc.和美国制药协会。
This study describes the characterization of the plasticizing properties of ibuprofen (IBP) on hot-melt extruded ethyl cellulose (EC). The thermal behavior of hot-melt extrudates containing 0, 5, 10, and 20% (w/w) IBP was evaluated using modulated temperature differential scanning calorimetry. By means of comparison, co-evaporates containing the same concentrations of IBP and EC, were also evaluated. Both methods yielded solid solutions having one glass transition temperature indicating compatibility between drug and polymer. A similar decrease in glass transition temperature was noticed with increasing IBP concentration in the solid solutions prepared via both methods, indicating its plasticizing effect. The plasticizing efficiency was of the same magnitude as for the traditionally used plasticizers. Infrared spectroscopy was performed for better understanding of the chemical interactions in the molecular dispersions and confirmed the existence of hydrogen bonds between IBP and EC. Overall, the study has highlighted the plasticizing properties of IBP on EC during hot-melt extrusion. (C) 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association.