The power law of sensory adaptation: Simulation by a model of excitability in spider mechanoreceptor neurons
The power law of sensory adaptation: Simulation by a model of excitability in spider mechanoreceptor neurons
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DOI：
10.1007/s10439-007-9392-9
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发表时间：
2008-01-01
影响因子：
3.8
通讯作者：
Torkkeli, Paivi H.
中科院分区：
文献类型：
--
作者：
French, Andrew S.;Torkkeli, Paivi H.
感觉适应的幂律是在50多年前提出的。其特征在于动作电位适应遵循时间或频率的分数幂，而不是指数衰减和相应的频率响应。幂律适应描述了一系列脊椎动物和无脊椎动物感觉感受器对确定性刺激（如台阶或正弦曲线）和随机（白色噪声）刺激的反应。关于幂律适应的物理基础的假说自幂律被发现以来就一直存在。其原因仍然是个谜，但在某些制剂中，幂律适应的位点位于受体电位向动作电位的转换中。在这里，我们使用伪随机噪声刺激和直接谱估计表明，只包含两个电压激活电流的模拟可以再现两种类型的蜘蛛mechanoreceptors的幂律适应。相同的模拟先前被用来解释这两种类型的感觉神经元对阶跃输入的不同反应。我们的结论是幂律适应的结果在动作电位编码的非线性组合的少数激活和失活过程具有不同的指数时间常数。
The power law of sensory adaptation was introduced more than 50 years ago. It is characterized by action potential adaptation that follows fractional powers of time or frequency, rather than exponential decays and corresponding frequency responses. Power law adaptation describes the responses of a range of vertebrate and invertebrate sensory receptors to deterministic stimuli, such as steps or sinusoids, and to random (white noise) stimulation. Hypotheses about the physical basis of power law adaptation have existed since its discovery. Its cause remains enigmatic, but the site of power law adaptation has been located in the conversion of receptor potentials into action potentials in some preparations. Here, we used pseudorandom noise stimulation and direct spectral estimation to show that simulations containing only two voltage activated currents can reproduce the power law adaptation in two types of spider mechanoreceptors. Identical simulations were previously used to explain the different responses of these two types of sensory neurons to step inputs. We conclude that power law adaptation results during action potential encoding by nonlinear combination of a small number of activation and inactivation processes with different exponential time constants.