MR imaging correlates of white-matter pathology in a preterm baboon model.
MR imaging correlates of white-matter pathology in a preterm baboon model.
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磁共振成像与早产狒狒模型中的白质病理学相关。
DOI：
10.1038/pr.2011.33
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发表时间：
2012-02
影响因子：
3.6
通讯作者：
Neil, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Griffith, Jennifer L.;Shimony, Joshua S.;Cousins, Stephanie A.;Rees, Sandra E.;McCurnin, Donald C.;Inder, Terrie E.;Neil, Jeffrey J.
磁共振成像(MRI)的脑白质(WM)异常与早产儿神经发育障碍相关。我们评估了早产狒狒模型中MRI异常的组织病理学相关性。在妊娠125天(胎龄185dg)出生，在动物重症监护室饲养14天(n=26)或28天(n=17)。妊娠对照动物出生于140dg(n=9)或153dg(n=4)。用MRI、弥散张量成像(DTI)和组织病理学方法评价固定脑的脑WM。WM和脑室容量的定量组织学测量与WM容量丢失和脑室增大的定性MRI评分相关。弥漫性星形细胞增多症与T2加权像信号异常和WM表观弥散系数高有关。少突胶质细胞的丢失与较低的相对各向异性有关，这些各向异性以较高的径向扩散系数为特征。组织病理学和MRI异常之间的关系在28d模型的动物中更加明显，相当于术语人类婴儿。MRI反映的显微结构和解剖异常是早产儿脑WM损伤的特征，这些变化在足月等月经后年龄的MRI上更加明显。
Cerebral white matter (WM) abnormalities on magnetic resonance imaging (MRI) correlate with neurodevelopmental disability in infants born prematurely. We assessed the histopathological correlates of MRI abnormalities in a baboon model of premature birth. Baboons were delivered at 125 days gestation (dg, term ~ 185 dg) and maintained in an animal intensive care unit for 14 (n = 26) or 28 days (n = 17). Gestational control animals were delivered at 140 dg (n = 9) or 153 dg (n = 4). Cerebral WM in fixed brains was evaluated using MRI, diffusion tensor imaging (DTI), and histopathology. Quantitative histological measures of WM and ventricular volumes correlated with qualitative MRI scores of WM volume loss and ventriculomegaly. Diffuse astrocytosis was associated with signal abnormality on T2-weighted imaging and higher apparent diffusion coefficient in WM. Loss of oligodendrocytes was associated with lower relative anisotropy characterized by higher radial diffusivity values. The relationship between histopathology and MRI abnormalities was more pronounced in animals in the 28 d model, equivalent to the term human infant. MRI reflects microstructural and anatomical abnormalities that are characteristic of WM injury in the preterm brain, and these changes are more evident on MRI at term equivalent postmenstrual age.
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影响因子：
8
作者：
H端ppi, PS;Murphy, B;Volpe, JJ
通讯作者：
Volpe, JJ
影响因子：
2.9
作者：
Drobyshevsky, Alexander;Bregman, Joanne;Tan, Sidhartha
通讯作者：
Tan, Sidhartha
影响因子：
5.1
作者：
Inder, TE;Wells, SJ;Volpe, JJ
通讯作者：
Volpe, JJ
影响因子：
11
作者：
GILLES, FH;MURPHY, SF
通讯作者：
MURPHY, SF
影响因子：
5.1
作者：
Maalouf, EF;Duggan, PJ;Edwards, AD
通讯作者：
Edwards, AD