An update on immunotherapy for food allergy.
An update on immunotherapy for food allergy.
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DOI：
10.1097/aci.0b013e32833fd5eb
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发表时间：
2010-12
影响因子：
2.8
通讯作者：
Jones SM
中科院分区：
文献类型：
--
作者：
Scurlock AM;Jones SM
最近的研究在确定食物过敏的治疗方案方面取得了重大进展。在这篇综述中，我们将探索积极治疗食物过敏的新的免疫治疗干预措施。由于食物过敏原免疫治疗的注射途径与严重过敏反应的不可接受的风险有关，因此使用粘膜靶向治疗策略对食物过敏具有重要意义。在动物和人体试验中，过敏原特异性免疫治疗方法，如口服、舌下、皮肤和多肽免疫治疗，在提高阈值剂量和诱导与脱敏和口服耐受相关的免疫学变化方面显示出有效性。更多的全球免疫调节策略，如中医药和抗IgE疗法，已被证明能有效地针对过敏反应，临床试验正在进行中，以确定其对人类食物过敏的有效性和安全性。针对粘膜免疫反应以促进口服耐受的治疗方法的出现，在食物过敏的治疗中显示出巨大的前景。然而，与这些治疗策略相关的不良反应风险仍然很大，还需要进一步的研究，以谨慎地将这些治疗方法推向全面的临床实施。
Recent investigation has resulted in significant advances toward definitive therapeutic options for food allergy. In this review, we will explore novel immunotherapeutic interventions for the active treatment of food allergy. Because the injection route for allergen immunotherapy to foods has been associated with an unacceptable risk of severe anaphylactic reactions, use of mucosally targeted therapeutic strategies is of significant interest for food allergy. Allergen-specific immunotherapeutic approaches such as oral, sublingual, epicutaneous, and peptide immunotherapy have demonstrated efficacy in increasing threshold dose and inducing immunologic changes associated with both desensitization and oral tolerance in animal and human trials. More global immunomodulatory strategies, such as Traditional Chinese Medicine and anti-IgE therapy have been shown to effectively target the allergic response, and clinical trials are ongoing to determine the efficacy and safety in human food allergy. The advent of therapies that target the mucosal immune response to promote oral tolerance have shown great promise in the treatment of food hypersensitivity. However, there is still significant risk of adverse reactions associated with these therapeutic strategies and further study is needed to carefully advance these therapeutic modalities toward general clinical implementation.