Vitamin D and calcium intake in relation to type 2 diabetes in women
Vitamin D and calcium intake in relation to type 2 diabetes in women
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DOI：
10.2337/diacare.29.03.06.dc05-1961
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发表时间：
2006-03-01
期刊：
影响因子：
16.2
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
Pittas, AG;Dawson-Hughes, B;Hu, FB
研究设计与方法：在护士健康研究中，我们跟踪了83,779名没有糖尿病、心血管疾病或癌症病史的女性患2型糖尿病的基线。每2-4年评估一次从饮食和补充剂中摄取的维生素D和钙。在20年的随访中，我们记录了4843例2型糖尿病的事件。结果：在调整了多个潜在的混杂因素后，总维生素D摄入量与2型糖尿病之间没有关联。然而，与从补充剂中摄入维生素D的最高类别和最低类别相比，2型糖尿病的相对危险度(RR)为0.87(95%CI为0.75~1.00；趋势为P=0.04)。2型糖尿病的多变量相对危险度为0.79(0.70-0.9；P为Trend<；0.001)，与从所有来源摄入钙的最高类别和最低类别的比较，以及0.82(0.72-0.92；P为0.001)的比较。每日摄入1,200毫克钙和800单位维生素D与摄入600毫克和400单位钙和维生素D相比，2型糖尿病的风险降低33%，相对危险度为0.67(0.49-0.90)。结论：这项大型前瞻性研究的结果表明，维生素D和钙的摄入在降低2型糖尿病风险方面具有潜在的有益作用。
OBJECTIVE - The purpose of this study was to prospectively examine the association between vitamin D and calcium intake and risk of type 2 diabetes.RESEARCH DESIGN AND METHODS - in the Nurses' Health Study, we followed 83,779 women who had no history of diabetes, cardiovascular disease, or cancer at baseline for the development of type 2 diabetes. Vitamin D and calcium intake from diet and supplements was assessed every 2-4 years. During 20 years of follow-up, we documented 4,843 incident cases Of type 2 diabetes.RESULTS - After adjusting for multiple Potential confounders, there was no association between total vitamin D intake and type 2 diabetes. However, the relative risk (RR) Of type 2 diabetes was 0.87 (95% CI 0.75-1.00; P for trend = 0.04) comparing the highest with the lowest category Of Vitamin D intake from supplements. The multivariale RRs of type 2 diabetes were 0.79 (0.70-0.90; P for trend < 0.001) comparing the highest with the lowest category of calcium intake from all sources and 0.82 (0.72-0.92; P for trend < 0.001) comparing the highest with the lowest category of calcium intake from supplements. A combined daily intake of > 1,200 mg calcium and > 800 IU Vitamin D was associated with a 33% lower risk of type 2 diabetes with RR of 0.67 (0.49-0.90) compared with an intake of < 600 mg and 400 IU calcium and vitamin D, respectively.CONCLUSIONS - The results of this large prospective study Suggest a potential beneficial role for both vitamin D and calcium intake in reducing the risk of type 2 diabetes.