Epidemiological, clinical and genetic characterization of aplastic anemia patients in Pakistan
Epidemiological, clinical and genetic characterization of aplastic anemia patients in Pakistan
复制标题
DOI：
10.1007/s00277-018-3542-z
复制
发表时间：
2019-02-01
影响因子：
3.5
通讯作者：
Sultan, Aneesa
中科院分区：
文献类型：
--
作者：
Akram, Zaineb;Ahmed, Parvez;Sultan, Aneesa
再生障碍性贫血（AA）是巴基斯坦最严重的非恶性血液疾病，发病率仅次于地中海贫血。我们调查了2014年6月至2015年12月期间在我院报告的214例巴基斯坦患者队列中AA的各种流行病学，临床和遗传因素。对照组214名健康受试者被纳入流行病学和临床特征的比较。流行病学数据显示，男性中AA的发生率高出2.75倍。在10岁至29岁之间观察到一个发病高峰，随后稳步下降。AA与较低的社会经济地位，农村居住，和近亲结婚率高。AA患者血清粒细胞集落刺激因子和血小板生成素水平显著高于健康对照组（P
Aplastic anemia (AA) is the most serious non-malignant blood disorder in Pakistan, ranked second in prevalence, after thalassemia. We investigated various epidemiological, clinical, and genetic factors of AA in a Pakistani cohort of 214 patients reporting at our hospital between June 2014 and December 2015. A control group of 214 healthy subjects was included for comparison of epidemiological and clinical features. Epidemiological data revealed 2.75-fold higher frequency of AA among males. A single peak of disease onset was observed between ages 10 and 29years followed by a steady decline. AA was strongly associated with lower socioeconomic profile, rural residence, and high rate of consanguineous marriages. Serum granulocyte colony-stimulating factor and thrombopoietin levels were significantly elevated in AA patients, compared to healthy controls (P