Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility
Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility
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DOI：
10.1007/s11427-017-9272-2
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发表时间：
2018-12-01
影响因子：
9.1
通讯作者：
Sun, Haixiang
中科院分区：
文献类型：
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作者：
Ding, Lijun;Yan, Guijun;Sun, Haixiang
卵巢早衰(POF)是一种以恢复生育为目的的临床难治性疾病。在本研究中，脐带间充质干细胞在胶原支架上(胶原/UC-MSCs)可以通过FOXO3a和FOXO1的磷酸化在体外激活原始卵泡。将胶原/UC-MSCs移植到POF患者的卵巢中，挽救了整体卵巢功能，表现为雌二醇浓度升高，卵泡发育改善，有腔卵泡数量增加。移植胶原/UC-MSCs或UC-MSCs的POF患者均获得成功的临床妊娠。综上所述，胶原/UC-MSC移植可能为POF提供一种有效的治疗方法。
Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF.