Primary squamous cell carcinoma of the breast after cured bilateral breast cancer.
Primary squamous cell carcinoma of the breast after cured bilateral breast cancer.
复制标题
双侧乳腺癌治愈后的原发性乳腺鳞状细胞癌。
作者：
R. Porzio;Claudia Cordini;N. Orsi;F. Brigati;C. Paties;L. Cavanna
背景
乳腺原发性鳞状细胞癌 (SCC) 是一种罕见的侵袭性肿瘤，约占所有乳腺癌的 0.1%。在将肿瘤归类为真正的乳腺鳞状细胞癌之前，需要满足某些标准。它们是： i) 超过 90% 的恶性细胞必须是鳞状细胞来源； ii) 肿瘤独立于上覆皮肤和乳头； iii) 原发性 SCC 的其他部位已被排除。
病例报告
我们描述了一名有双侧乳腺癌病史的 54 岁女性，在原发性乳腺腺癌局部放疗 15 年后出现单纯乳腺鳞状细胞癌。肿瘤呈三阴性，Ki-67 指数较高。患者接受了多西紫杉醇和口服氟尿嘧啶的辅助化疗。
结论
对于原发性乳腺鳞状细胞癌的治疗没有具体的指南。需要更大规模的研究来确定是否需要不同的治疗和随访策略，以及预后是否确实与乳腺癌的其他组织类型具有可比性。
BACKGROUND
Primary squamous cell carcinoma (SCC) of the breast is a rare and aggressive neoplasm that constitutes approximately 0.1% of all breast carcinomas. Before the tumor can be classified as a true SCC of the breast, certain criteria need to be fulfilled. These are: i) more than 90% of the malignant cells must be of squamous cells origin; ii) tumor is independent from the overlying skin and nipple; iii) other sites of primary SCC have been excluded.
CASE REPORT
We describe a case of pure SCC of the breast that arose 15 years after local radiation for a primary adenocarcinoma of the breast in a 54-year-old woman with history of bilateral breast cancer. The tumor was triple-negative with a high Ki-67 index. The patient underwent adjuvant chemotherapy with docetaxel and oral fluorouracil.
CONCLUSION
There are no specific guidelines for the treatment of primary SCC of the breast. Larger series are necessary to determine if different strategies of treatment and follow-up are necessary and if prognosis is really comparable to other histotypes of cancers of the breast.