3D bioprinting of glioblastoma models.
3D bioprinting of glioblastoma models.
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DOI：
10.2217/3dp-2019-0027
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发表时间：
2020-06
期刊：
影响因子：
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通讯作者：
Carolina Parra-Cantu;Wanlu Li;A. Quiñones‐Hinojosa;Y. S. Zhang
中科院分区：
文献类型：
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作者：
Carolina Parra-Cantu;Wanlu Li;A. Quiñones‐Hinojosa;Y. S. Zhang
成人中最常见的恶性原发性脑肿瘤是胶质母细胞瘤（GBM）。需要体外3D脑模型来更好地理解GBM的病理过程，并最终开发更有效的抑制剂。在这里，我们描述了已用于制造体积GBM模型的生物打印方法。我们解释了3D生物打印应该考虑的几个因素，包括生物墨水，细胞和结构设计，与GBM建模有关。尽管3D生物打印的大脑模型仍有待改进，但它们有可能成为药物筛选的有力工具。
The most common and malignant primary brain tumor in adults is glioblastoma (GBM). In vitro 3D brain models are needed to better understand the pathological processes underlying GBM and ultimately develop more efficient antineoplastic agents. Here, we describe the bioprinting methods that have been used to fabricate volumetric GBM models. We explain several factors that should be considered for 3D bioprinting, including bioinks, cells and construct designs, in relation to GBM modeling. Although 3D-bioprinted brain models are still to be improved, they have the potential to become a powerful tool for drug screening.