Disease Remission State in Patients Treated With the Combination of Tumor Necrosis Factor Blockade and Methotrexate or With Disease-Modifying Antirheumatic Drugs A Clinical and Imaging Comparative Study
Disease Remission State in Patients Treated With the Combination of Tumor Necrosis Factor Blockade and Methotrexate or With Disease-Modifying Antirheumatic Drugs A Clinical and Imaging Comparative Study
复制标题
DOI：
10.1002/art.24596
复制
发表时间：
2009-07-01
影响因子：
--
通讯作者：
Emery, Paul
中科院分区：
文献类型：
--
作者：
Saleem, Benazir;Brown, Andrew K.;Emery, Paul
客观的。对于正在接受缓解病情抗风湿药物 (DMARD) 的缓解期类风湿关节炎 (RA) 患者，放射学进展与通过功率多普勒活动测量的影像学检测滑膜炎相关。相比之下，接受肿瘤坏死因子 (TNF) 阻断与甲氨蝶呤 (MTX) 联合治疗（联合治疗）的疾病缓解患者在同等临床状态下减少了放射学损伤。我们进行这项研究是为了确定放射学结果的差异是否是更完全抑制影像检测滑膜炎的结果。方法。 100 名 RA 患者处于缓解状态（28 个关节的疾病活动评分 [DAS28] = 48% 的患者，无论接受何种治疗）。这些结果表明，接受 TNF 阻断和 MTX 联合治疗的患者的放射学结果优异，可能并不是因为完全抑制了影像学检测到的滑膜炎。
Objective. For patients with rheumatoid arthritis (RA) in remission who are receiving disease-modifying antirheumatic drugs (DMARDs), radiographic progression correlates with imaging-detected synovitis as measured by power Doppler activity. In contrast, patients with disease in remission who are receiving the combination of tumor necrosis factor (TNF) blockade with methotrexate (MTX) (combination treatment) have reduced radiographic damage for the equivalent clinical state. We undertook this study to determine whether the difference in radiographic outcome is a result of more complete suppression of imaging-detected synovitis.Methods. One hundred patients with RA in remission (Disease Activity Score in 28 joints [DAS28] = 48% of the patients regardless of therapy. These results suggest that superior radiographic outcomes in patients treated with the combination of TNF blockade and MTX may not be due to complete suppression of imaging-detected synovitis.