The biology of human malignant melanoma. Preliminary findings in the nude mouse.
The biology of human malignant melanoma. Preliminary findings in the nude mouse.
复制标题
人类恶性黑色素瘤的生物学。
作者：
L. Barr;R. L. Gartside;L. Goldman
裸鼠模型被探索作为预测人类皮肤恶性黑色素瘤行为的一种手段。观察 20 名患者的皮下植入物的外部生长、显微镜外观和氚化胸苷标记后的放射自显影分析。六个低风险的初级植入物中保留了正常的上皮和真皮成分，但没有任何外部生长或肿瘤细胞保存。五个转移性植入物中的四个在整个观察期间不断生长，计数的肿瘤细胞中有 30% 吸收了放射性同位素。九个高风险初次植入物中有四个生长速度较慢，其中八个肿瘤细胞保留。只有 6% 的计数肿瘤细胞掺入了氚化胸苷。该模型似乎能够区分各种形式的人类恶性黑色素瘤的行为。
The nude mouse model was explored as a means of predicting the behavior of human cutaneous malignant melanoma. Subcutaneous implants from 20 patients were observed for external growth, microscopic appearance, and autoradiographic analyses following tritiated thymidine labeling. Normal epithelial and dermal components were maintained in the six low-risk primary implants, but none had any external growth or tumor cell preservation. Four of the five metastatic implants grew throughout the observation periods, with 30% of the counted tumor cells taking up the radioisotope. There was a slower growth rate in four of nine high-risk primary implants, with tumor cell preservation in eight. Only 6% of the counted tumor cells incorporated tritiated thymidine. This model appears to be capable of discriminating among the behavior of various forms of human malignant melanoma.